INT24761

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Context Info
Confidence 0.49
First Reported 1989
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.86
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SST) extracellular region (SST) cell-cell signaling (SST)
SST (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 12 100.00 Very High Very High Very High
Somatostatin 4 100.00 Very High Very High Very High
peptic ulcer disease 1 79.32 Quite High
Bioavailability 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 3 99.20 Very High Very High Very High
Cystadenocarcinoma 2 82.72 Quite High
Thyroid Disease 28 82.60 Quite High
Disease 2 79.32 Quite High
Ulcers 1 79.00 Quite High
Metabolic Disorder 2 5.00 Very Low Very Low Very Low
Hypothyroidism 2 5.00 Very Low Very Low Very Low
Growth Problems 2 5.00 Very Low Very Low Very Low
Liver Disease 1 5.00 Very Low Very Low Very Low
Malabsorption Syndromes 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This report demonstrates secretin stimulation and somatostatin inhibition of gastrin secretion from a cell that is apparently not of endocrine origin.
Positive_regulation (demonstrates) of Negative_regulation (inhibition) of somatostatin associated with somatostatin
1) Confidence 0.49 Published 1989 Journal Gastroenterology Section Abstract Doc Link 2473000 Disease Relevance 0.59 Pain Relevance 0.17
As this effect is probably mediated by two different mechanisms, i.e. via increased endogenous GHRH for CLON and via inhibition of endogenous somatostatin for PD, in 8 normal children we studied the effect of both single and combined acute oral administration of CLON (150 micrograms/m2) and PD (60 mg).
Spec (probably) Positive_regulation (mediated) of Negative_regulation (inhibition) of somatostatin associated with somatostatin and clonidine
2) Confidence 0.49 Published 1989 Journal J. Endocrinol. Invest. Section Abstract Doc Link 2754188 Disease Relevance 0 Pain Relevance 0.78
The last phenomenon has been explained by an increase of somatostatin (being a natural TSH inhibitor) in the patients on rhGH therapy [15].
Positive_regulation (increase) of Negative_regulation (inhibitor) of somatostatin associated with somatostatin
3) Confidence 0.49 Published 2010 Journal Thyroid Res Section Body Doc Link PMC2858102 Disease Relevance 0.27 Pain Relevance 0.05

General Comments

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