INT247617

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.30
Pain Relevance 2.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PAMR1)
PAMR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nav1.7 60 99.34 Very High Very High Very High
Paroxysmal extreme pain disorder 84 95.52 Very High Very High Very High
Pain 40 90.56 High High
addiction 30 86.80 High High
carbamazepine 22 82.16 Quite High
dorsal root ganglion 64 65.36 Quite High
sodium channel 18 63.40 Quite High
Nav1.9 2 44.36 Quite Low
nav1.8 2 43.92 Quite Low
nociceptor 8 42.32 Quite Low
Disease Link Frequency Relevance Heat
Erythermalgia 32 99.16 Very High Very High Very High
Somatoform Disorder 84 95.52 Very High Very High Very High
Pain 34 90.56 High High
Convulsion 4 83.32 Quite High
Heart Rate Under Development 4 82.00 Quite High
Syncope 2 80.44 Quite High
Disease 8 70.00 Quite High
Ganglion Cysts 66 65.36 Quite High
Cognitive Disorder 2 50.24 Quite High
Targeted Disruption 4 42.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have also observed that M1627K display an increased ramp current, similar to IEM mutations [13,16,17,21-25].
Positive_regulation (increased) of ramp associated with erythermalgia
1) Confidence 0.06 Published 2008 Journal Mol Pain Section Body Doc Link PMC2556659 Disease Relevance 0.70 Pain Relevance 0.85
Whole-cell voltage-clamp studies have shown that all of the IEM mutations lower the voltage threshold for Nav1.7 activation, with most mutations increasing the ramp response of the channel [13,16,17,21-25].
Positive_regulation (increasing) of ramp associated with erythermalgia and nav1.7
2) Confidence 0.05 Published 2008 Journal Mol Pain Section Body Doc Link PMC2556659 Disease Relevance 1.60 Pain Relevance 1.21

General Comments

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