INT247639

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.09
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 3.06
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Jun, Atf3) DNA binding (Jun, Atf3) cytosol (Jun)
aging (Jun) nucleolus (Atf3) transcription factor binding (Jun)
Anatomy Link Frequency
neuronal 3
Jun (Rattus norvegicus)
Atf3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 15 92.32 High High
Peripheral nerve injury 2 89.56 High High
Inflammation 17 85.52 High High
Spinal cord 44 5.00 Very Low Very Low Very Low
Sciatic nerve 17 5.00 Very Low Very Low Very Low
Inflammatory response 12 5.00 Very Low Very Low Very Low
Neuropeptide 10 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 50 99.76 Very High Very High Very High
Injury 92 99.60 Very High Very High Very High
Stress 11 98.64 Very High Very High Very High
Shock 1 96.48 Very High Very High Very High
Nervous System Injury 7 93.48 High High
Ganglion Cysts 17 92.32 High High
Targeted Disruption 2 87.20 High High
INFLAMMATION 29 85.52 High High
Leukemia 1 67.24 Quite High
Spinal Cord Injury 58 64.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hsp27 is a downstream product of the dimerisation of ATF-3 and c-Jun, another transcription factor usually up-regulated after axotomy [53] that was not examined in the current study. c-Jun has been associated with apoptosis, neuronal survival, as well as regeneration [53].
Jun Binding (associated) of ATF-3 in neuronal associated with apoptosis
1) Confidence 0.09 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 1.08 Pain Relevance 0.22
Hsp27 is a downstream product of the dimerisation of ATF-3 and c-Jun, another transcription factor usually up-regulated after axotomy [53] that was not examined in the current study. c-Jun has been associated with apoptosis, neuronal survival, as well as regeneration [53].
Jun Binding (associated) of ATF-3 in neuronal associated with apoptosis
2) Confidence 0.09 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 1.08 Pain Relevance 0.22
ATF3 as a heterodimer with c-Jun promotes neuronal survival under stress by induction of the anti-apoptotic factor heat shock protein 27 [45].
c-Jun Binding (heterodimer) of ATF3 in neuronal associated with stress, shock and apoptosis
3) Confidence 0.03 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2556676 Disease Relevance 0.91 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox