INT247662

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Context Info
Confidence 0.68
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.51
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TNNI3) cytoplasm (TNNI3)
TNNI3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 2 92.24 High High
anesthesia 7 5.00 Very Low Very Low Very Low
ischemia 6 5.00 Very Low Very Low Very Low
Catecholamine 6 5.00 Very Low Very Low Very Low
aspirin 5 5.00 Very Low Very Low Very Low
Ultiva 5 5.00 Very Low Very Low Very Low
cva 5 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sepsis 39 99.68 Very High Very High Very High
Death 130 96.80 Very High Very High Very High
Systemic Inflammatory Response Syndrome 13 92.96 High High
Injury 31 91.88 High High
Necrosis 23 89.80 High High
Acute Coronary Syndrome 5 85.44 High High
Cytomegalovirus Infection 5 82.44 Quite High
Coagulation Disorder 7 80.40 Quite High
Thrombosis 5 75.00 Quite High
Pulmonary Disease 10 63.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since we previously found in elective CABG surgery that the overall amount of cardiac cells injured (whatever the mechanisms of myocardial tissue insult) was reflected by postoperative cTnI release and was well correlated with the short-term and long-term clinical outcome [12], it is probable that both an increase in basal postoperative cTnI release and the worst outcome are linked in combined surgery.
Positive_regulation (increase) of Localization (release) of cTnI
1) Confidence 0.68 Published 2007 Journal Crit Care Section Body Doc Link PMC2556750 Disease Relevance 0.30 Pain Relevance 0
To date no data regarding coagulation disturbances as a possible mechanism for cTnI release during sepsis are available.


Spec (possible) Positive_regulation (mechanism) of Localization (release) of cTnI associated with sepsis
2) Confidence 0.49 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2815772 Disease Relevance 1.13 Pain Relevance 0.05
Fourth, our study provides some insights into the different mechanisms involved in 'basal' and pathological postoperative cTnI release in main types of adult cardiac surgery with CPB, but do not test appropriate strategies to improve outcome in identified high-risk patients.
Positive_regulation (postoperative) of Localization (release) of cTnI
3) Confidence 0.49 Published 2007 Journal Crit Care Section Body Doc Link PMC2556750 Disease Relevance 0.07 Pain Relevance 0
An elevated postoperative cTnI release was a strong and independent predictor of severe cardiac events and inhospital death after conventional cardiac surgery, whatever the type of surgery.
Positive_regulation (elevated) of Localization (release) of cTnI associated with death
4) Confidence 0.49 Published 2007 Journal Crit Care Section Body Doc Link PMC2556750 Disease Relevance 0.35 Pain Relevance 0
The sequences of the primers used for the amplification of insulin receptor (IR), cardiac troponin T (cTNT) and GAPDH RNAs are: IR (forward 5?
Positive_regulation (used) of Localization (amplification) of cardiac troponin T
5) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597774 Disease Relevance 0.15 Pain Relevance 0
Postoperative cTnI release was significantly different among the three groups of surgery. cTnI was increased in patients undergoing combined surgery when compared with CABG patients and valve surgery patients, while CABG surgery was associated with the lowest postoperative cTnI level.
Positive_regulation (increased) of Localization (release) of cTnI
6) Confidence 0.45 Published 2007 Journal Crit Care Section Body Doc Link PMC2556750 Disease Relevance 0.26 Pain Relevance 0
The more the procedure is complex and prolonged, the more the cTnI release is increased, irrespective of the mechanism.

• Different thresholds of postoperative cTnI release should be considered according to the procedure type in clinical practice to predict early a poor outcome following conventional adult cardiac surgery with CPB. • Despite the determination of a particular threshold of postoperative cTnI release in each type of cardiac surgery, the accuracy of cTnI to predict a poor outcome following conventional adult cardiac surgery with CPB may be different among procedure types, being less accurate in combined surgery and in valve surgery than in coronary surgery.


Positive_regulation (increased) of Localization (release) of cTnI
7) Confidence 0.45 Published 2007 Journal Crit Care Section Body Doc Link PMC2556750 Disease Relevance 0.25 Pain Relevance 0

General Comments

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