INT247709

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Context Info
Confidence 0.14
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 11
Disease Relevance 0.68
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cmklr1) plasma membrane (Cmklr1) signal transducer activity (Cmklr1)
Anatomy Link Frequency
macrophages 3
NK cells 1
mast cells 1
Cmklr1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 66 99.38 Very High Very High Very High
chemokine 363 98.60 Very High Very High Very High
Inflammatory response 33 90.04 High High
Inflammation 88 77.60 Quite High
agonist 11 69.04 Quite High
Potency 22 65.52 Quite High
ketamine 11 5.00 Very Low Very Low Very Low
anesthesia 11 5.00 Very Low Very Low Very Low
Bioavailability 11 5.00 Very Low Very Low Very Low
Multiple sclerosis 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 121 89.64 High High
Anaphylaxis 319 76.08 Quite High
Edema 209 73.24 Quite High
Contact Dermatitis 77 68.68 Quite High
Hemorrhage 11 34.48 Quite Low
Disease 22 5.00 Very Low Very Low Very Low
Hypersensitivity 22 5.00 Very Low Very Low Very Low
Demyelinating Disease 11 5.00 Very Low Very Low Very Low
Overdose 11 5.00 Very Low Very Low Very Low
Lymphatic System Cancer 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data indicate that at some point before 24 h after activation by TLR ligands or proinflammatory cytokines, macrophages can concurrently express both chemerin receptors CMKLR1 and CCRL2.
Gene_expression (express) of CMKLR1 in macrophages associated with cytokine
1) Confidence 0.14 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0.10
mCMKLR1-HA, huCCRL2-HA, and mCCRL2-HA L1.2 transfectants were incubated for 15 min with 100 nM serum form chemerin at the indicated temperature in cell culture media.
Gene_expression (transfectants) of mCMKLR1-HA
2) Confidence 0.12 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0
For competition binding assays, L1.2 cells transfected with huCCRL2, mCCRL2, or mCMKLR1 were plated into 96-well plates at 0.5 × 106 cells/well.
Gene_expression (transfected) of mCMKLR1
3) Confidence 0.12 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0
Our data indicate that at some point before 24 h after activation by TLR ligands or proinflammatory cytokines, macrophages can concurrently express both chemerin receptors CMKLR1 and CCRL2.
Gene_expression (receptors) of CMKLR1 in macrophages associated with cytokine
4) Confidence 0.12 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0.10
CMKLR1 is expressed by circulating human plasmacytoid DC (pDC) but not by circulating or tissue mouse DC (20, 23).
Neg (not) Gene_expression (expressed) of CMKLR1
5) Confidence 0.11 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.15 Pain Relevance 0.46
A recent study by Parolini et al. (24) describes CMKLR1 expression by human NK cells.
Gene_expression (expression) of CMKLR1 in NK cells
6) Confidence 0.11 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.16 Pain Relevance 0.34
mCMKLR1-HA and mCCRL2-HA L1.2 transfectants were loaded for 30 min on ice with primary antibody (anti-HA or mIgG1 isotype control).
Gene_expression (transfectants) of mCMKLR1-HA
7) Confidence 0.10 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0
Interestingly, we were unable to detect chemerin binding to mCMKLR1-HA/L1.2 transfectants in the immunofluorescence chemerin binding assay (Fig. 6 D).
Gene_expression (transfectants) of mCMKLR1-HA
8) Confidence 0.09 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0.06
Chemerin triggered a robust calcium flux in cells expressing the chemerin signaling receptor mCMKLR1, confirming its activity (Fig. 7 A). mCCRL2-HA/L1.2 transfectants responded to CXCL12 (via endogenous CXCR4), indicating their competence for demonstrating calcium mobilization in this assay (Fig. 7 A).
Gene_expression (expressing) of mCMKLR1
9) Confidence 0.09 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0.03
In contrast, tissue resident macrophages in both humans and mice express CMKLR1 (23).
Gene_expression (express) of CMKLR1 in macrophages
10) Confidence 0.09 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.15 Pain Relevance 0.38
S11 shows the lack of mCMKLR1 expression on peritoneal mast cells.
Gene_expression (expression) of mCMKLR1 in mast cells
11) Confidence 0.09 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.22 Pain Relevance 0.03

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