INT247736

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Context Info
Confidence 0.52
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.52
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Rarres2)
Anatomy Link Frequency
leukocyte 1
reservoir 1
Rarres2 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 132 95.60 Very High Very High Very High
cytokine 24 78.00 Quite High
Inflammation 32 77.20 Quite High
Inflammatory response 12 64.12 Quite High
Potency 8 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
Multiple sclerosis 4 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Edema 76 96.12 Very High Very High Very High
INFLAMMATION 44 77.20 Quite High
Anaphylaxis 116 60.12 Quite High
Contact Dermatitis 28 11.92 Low Low
Disease 8 5.00 Very Low Very Low Very Low
Hypersensitivity 8 5.00 Very Low Very Low Very Low
Demyelinating Disease 4 5.00 Very Low Very Low Very Low
Overdose 4 5.00 Very Low Very Low Very Low
Lymphatic System Cancer 4 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to mCCRL2/L1.2 transfectants, however, at the 60-min time point there was a considerable reduction in surface-bound chemerin (Fig. 8 D, PBS wash), suggesting either eventual extracellular degradation or chemerin release.
Localization (release) of chemerin
1) Confidence 0.52 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0
The cells were then incubated for the indicated times at 37°C to allow for chemerin internalization.
Localization (internalization) of chemerin
2) Confidence 0.48 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0
CCRL2 expression by stromal cells in the lung and heart may serve to maintain a reservoir of chemerin and to buffer tissue levels of the attractant in vivo in the same manner that erythrocyte-expressed atypical chemokine receptor DARC can serve as a buffer to maintain chemokine levels in the blood (14, 15).
Localization (reservoir) of chemerin in reservoir associated with chemokine
3) Confidence 0.46 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0.13
We propose that CCRL2 is a novel attractant receptor, serving to focus chemerin localization in vivo and contribute to CMKLR1-mediated processes that, in turn, regulate pathways leading to increased vascular permeability, tissue swelling, and leukocyte recruitment.
Localization (localization) of chemerin in leukocyte associated with edema
4) Confidence 0.46 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.52 Pain Relevance 0.16

General Comments

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