INT247739

Context Info Confidence 0.11 First Reported 2008 Last Reported 2008 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0 Pain Relevance 0.54

signal transduction (Ccbp2) plasma membrane (Ccbp2) signal transducer activity (Ccbp2)

Anatomy Link Frequency leukocytes 1 Ccbp2 (Mus musculus)

Pain Link Frequency Relevance Heat chemokine 66 99.20 rheumatoid arthritis 2 40.60 agonist 2 38.76 Inflammatory response 6 23.92 Inflammation 16 22.28 Multiple sclerosis 2 11.72 cytokine 12 5.00 Potency 4 5.00 ketamine 2 5.00 anesthesia 2 5.00

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 2 40.60 INFLAMMATION 22 23.92 Disease 4 14.88 Demyelinating Disease 2 11.72 Multiple Sclerosis 2 10.20 Anaphylaxis 58 5.00 Edema 38 5.00 Contact Dermatitis 14 5.00 Hypersensitivity 4 5.00 Overdose 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Our data place CCRL2 in a class of atypical receptors that include D6, DARC, and CCX-CKR, all of which bind to chemoattractants but do not support classical ligand-driven signal transduction (for review see reference 11).

D6 Neg (not) Binding (bind) of

1) Confidence 0.11 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0.08

D6 is expressed by lymphatic endothelium and by some leukocytes and binds proinflammatory CC chemokines.

D6 Binding (binds) of in leukocytes associated with chemokine

2) Confidence 0.09 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0.45

General Comments

This test has worked.