INT247747

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Context Info
Confidence 0.44
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.36
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ccrl2) plasma membrane (Ccrl2) signal transducer activity (Ccrl2)
Anatomy Link Frequency
macrophages 1
leukocytes 1
Astrocytes 1
microglia 1
Ccrl2 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 132 96.76 Very High Very High Very High
Inflammation 32 94.88 High High
Multiple sclerosis 4 93.08 High High
cytokine 24 84.80 Quite High
rheumatoid arthritis 4 58.88 Quite High
Bioavailability 4 50.56 Quite High
Inflammatory response 12 5.00 Very Low Very Low Very Low
Potency 8 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 8 96.24 Very High Very High Very High
INFLAMMATION 44 94.88 High High
Demyelinating Disease 4 93.08 High High
Multiple Sclerosis 4 91.56 High High
Anaphylaxis 116 86.08 High High
Hypersensitivity 8 80.56 Quite High
Edema 76 74.96 Quite High
Rheumatoid Arthritis 4 58.88 Quite High
Contact Dermatitis 28 5.00 Very Low Very Low Very Low
Overdose 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, it is interesting to note that CCRL2 and CMKLR1 on macrophages are reciprocally regulated (e.g., LPS causes down-regulation of CMKLR1 but up-regulation of CCRL2 (Fig.
Regulation (regulated) of CCRL2 in macrophages
1) Confidence 0.44 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.12 Pain Relevance 0.08
In its role as a specialized molecule for concentrating extracellular chemerin, CCRL2 may operate akin to glycosaminoglycans, which are thought to bind, concentrate, and present chemokines to leukocytes and facilitate their chemotaxis (38).
Spec (may) Regulation (operate) of CCRL2 in leukocytes associated with chemokine
2) Confidence 0.20 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.37 Pain Relevance 0.07
Astrocytes and microglia also up-regulate mCCRL2 in response to LPS (5).
Regulation (regulate) of mCCRL2 in microglia
3) Confidence 0.17 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.43 Pain Relevance 0.24
Astrocytes and microglia also up-regulate mCCRL2 in response to LPS (5).
Regulation (regulate) of mCCRL2 in Astrocytes
4) Confidence 0.06 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.43 Pain Relevance 0.24

General Comments

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