INT247751

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Context Info
Confidence 0.25
First Reported 2008
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 0.75
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gopc) Golgi apparatus (Gopc) plasma membrane (Gopc)
cytoplasm (Gopc)
Anatomy Link Frequency
brain 2
Gopc (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 34 99.82 Very High Very High Very High
Analgesic 61 83.92 Quite High
Opioid 10 81.20 Quite High
Cannabinoid 54 80.24 Quite High
mu opioid receptor 26 75.28 Quite High
addiction 4 75.12 Quite High
midbrain 2 73.52 Quite High
Rostral ventromedial medulla 4 68.80 Quite High
agonist 60 61.80 Quite High
substantia gelatinosa 1 61.28 Quite High
Disease Link Frequency Relevance Heat
Stress 31 94.48 High High
Edema 19 78.04 Quite High
Anaphylaxis 29 74.00 Quite High
Urological Neuroanatomy 10 69.36 Quite High
Targeted Disruption 13 55.44 Quite High
Nociception 3 53.12 Quite High
Death 1 30.00 Quite Low
Cancer 8 15.60 Low Low
Apoptosis 6 6.80 Low Low
INFLAMMATION 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
max of the pigment used for normalization (Fig. 2E), produced a Gaussian distribution peaking at 497.3 nm, remarkably close to the mouse rod ?
Positive_regulation (used) of Fig Binding (normalization) of
1) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993945 Disease Relevance 0 Pain Relevance 0
Fluorescence microscopy revealed that the enriched library showed enhanced binding to the brain sections, compared to the naive library (Fig. 1).
Positive_regulation (enhanced) of Fig Binding (binding) of in brain
2) Confidence 0.22 Published 2010 Journal Pharm Res Section Body Doc Link PMC2837178 Disease Relevance 0 Pain Relevance 0
M, promoted the internalization of the CB1Rs (Fig. 2C and 2D).
Positive_regulation (promoted) of Fig Binding (internalization) of
3) Confidence 0.18 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657119 Disease Relevance 0.12 Pain Relevance 0.50
These chemokines did not induce migration of mCCRL2/L1.2 transfectants in our in vitro transwell chemotaxis assays (Fig.
Neg (not) Positive_regulation (induce) of Fig Binding (migration) of associated with chemokine
4) Confidence 0.16 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.21 Pain Relevance 0.05
A truncated Sox17 isoform (t-Sox17), which lacks most of the HMG box and cannot bind DNA [34], did not affect cyclin D1 promoter activity (Fig. 6C), indicating that activation of cyclin D1-luciferase reporters by Sox17 requires DNA binding.
Positive_regulation (requires) of Fig Binding (binding) of
5) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
Some of these findings were demonstrated in a model accounting for the degradation of the NRF2 transcription factor by CRIF1 and KEAP1 (see Fig. 9 and its legend).
Positive_regulation (see) of Fig Binding (legend) of
6) Confidence 0.11 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0.29 Pain Relevance 0
M nostressin did not induce alternative splicing of XBP-1 (Fig. 3C).
Neg (not) Positive_regulation (induce) of Fig Neg (not) Binding (splicing) of
7) Confidence 0.06 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2803434 Disease Relevance 0.13 Pain Relevance 0.03
However, actin recruitment required both nucleotides; the sole presence of GMP-PNP did not mediate recruitment of NMM or actin (Fig. 3A).
Neg (not) Positive_regulation (mediate) of Fig Neg (not) Binding (recruitment) of
8) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2975642 Disease Relevance 0 Pain Relevance 0.04

General Comments

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