INT247764

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.29
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ccrl2) plasma membrane (Ccrl2) signal transducer activity (Ccrl2)
Anatomy Link Frequency
mast cell 2
Ccrl2 (Mus musculus)
Fcer2a (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 33 75.20 Quite High
Inflammation 8 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Multiple sclerosis 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anaphylaxis 29 98.08 Very High Very High Very High
Edema 19 96.52 Very High Very High Very High
INFLAMMATION 11 5.00 Very Low Very Low Very Low
Contact Dermatitis 7 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Hypersensitivity 2 5.00 Very Low Very Low Very Low
Demyelinating Disease 1 5.00 Very Low Very Low Very Low
Overdose 1 5.00 Very Low Very Low Very Low
Lymphatic System Cancer 1 5.00 Very Low Very Low Very Low
Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We show that the mast cell–expressed orphan serpentine receptor mCCRL2 is not required for expression of IgE-mediated mast cell–dependent passive cutaneous anaphylaxis but can enhance the tissue swelling and leukocyte infiltrates associated with such reactions in mice.
mCCRL2 Neg (not) Positive_regulation (required) of Gene_expression (expression) of IgE in mast cell associated with anaphylaxis and edema
1) Confidence 0.01 Published 2008 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2556791 Disease Relevance 0.29 Pain Relevance 0.04

General Comments

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