INT247794

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Context Info
Confidence 0.76
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.17
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxadr) extracellular region (Cxadr) cell adhesion (Cxadr)
mitochondrion organization (Cxadr) plasma membrane (Cxadr) nucleus (Cxadr)
Anatomy Link Frequency
cardiomyocytes 3
CAR 1
Cxadr (Mus musculus)
Pain Link Frequency Relevance Heat
Substantia nigra 36 99.68 Very High Very High Very High
anesthesia 20 78.40 Quite High
Central nervous system 18 77.84 Quite High
addiction 7 73.64 Quite High
Dopamine 36 50.00 Quite Low
fibrosis 3 26.28 Quite Low
imagery 9 5.00 Very Low Very Low Very Low
midbrain 6 5.00 Very Low Very Low Very Low
isoflurane 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 271 99.96 Very High Very High Very High
Rabies Virus Infection 2 94.20 High High
Heart Disease 9 85.24 High High
Parkinson's Disease 30 80.24 Quite High
Neurodegenerative Disease 6 79.08 Quite High
Disease 23 74.96 Quite High
Cytomegalovirus Infection 6 70.80 Quite High
Heart Rate Under Development 15 70.00 Quite High
Cancer 9 59.40 Quite High
Arrhythmia Under Development 57 41.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This indicates that CAR KO cardiomyocytes, unlike AV nodal cells are not limited by GAP junction activity, a feature which could derive both from altered expression of connexins and differential localization of CAR between the cell types (Fig. 3).
Localization (localization) of CAR in cardiomyocytes associated with targeted disruption
1) Confidence 0.76 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556793 Disease Relevance 0.94 Pain Relevance 0.04
To find a morphological correlate of the AV block and verify expression of CAR in AV nodal cells, we used various marker proteins to identify the AV node (Fig. 3) and documented differential localization of CAR in cardiomyocytes versus AV nodal cells (Fig. 3, E and F).
Localization (localization) of CAR in cardiomyocytes
2) Confidence 0.67 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556793 Disease Relevance 0.82 Pain Relevance 0.08
The underlying mechanism relates to the cross talk of tight and gap junctions with altered expression and localization of connexins that affect communication between CAR KO cardiomyocytes.
Localization (localization) of CAR in cardiomyocytes associated with targeted disruption
3) Confidence 0.58 Published 2008 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2556793 Disease Relevance 0.37 Pain Relevance 0
Together these observations suggest that the relative paucity of endogenous CAR accounts for the inability of Ad5 to infect dopaminergic neurons in wild type mice, and that in the hCAR transgenic animal the entry of the virus is facilitated by synaptically-localized CAR protein.
Localization (localized) of CAR in CAR associated with targeted disruption
4) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.51 Pain Relevance 0.15
In wild type mice, however, our western blot studies suggest that the overall abundance of mCAR in the SN is quite low, and we were unable to detect the endogenous mCAR protein by immunohistochemistry in the SN.
Localization (abundance) of mCAR associated with substantia nigra
5) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.52 Pain Relevance 0.18

General Comments

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