INT247798

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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.05
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Rasa1) plasma membrane (Rasa1) embryo development (Rasa1)
cytoplasm (Rasa1)
Anatomy Link Frequency
brachial plexus 2
Rasa1 (Mus musculus)
Pain Link Frequency Relevance Heat
Thalamus 2 87.24 High High
Neurotransmitter 4 67.24 Quite High
Spinal cord 50 62.84 Quite High
medulla 60 62.20 Quite High
cytokine 10 54.92 Quite High
metalloproteinase 2 44.44 Quite Low
Inflammatory mediators 2 40.08 Quite Low
Nerve growth factor 2 37.72 Quite Low
Inflammation 2 29.76 Quite Low
adenocard 1 10.12 Low Low
Disease Link Frequency Relevance Heat
Arrhythmias 2 Under Development 4 88.44 High High
Targeted Disruption 78 85.68 High High
Arrhythmia Under Development 19 84.48 Quite High
Hamartoma 8 77.44 Quite High
Death 4 76.04 Quite High
Apoptosis 3 71.88 Quite High
Adhesions 3 70.88 Quite High
Heart Disease 3 59.72 Quite High
Coxsackie Virus Infection 1 54.40 Quite High
Tuberous Sclerosis 11 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, when RGS2 was phosphorylated by PKC, GAP activity was reduced, then Gq/11 signals were enhanced [41]; RGS16 phosphorylation could also reduce its GAP activity toward GRi/o and result in increased adrenergic receptor signals [42], then the paralleled increase in RGS4 and PKA induced by brachial plexus avulsion will be expected to unmask their full functional potential, the orchestrated and dynamical RGS4 subcellular distribution and modulation will be the intriguing intracellular signal in response to brachial plexus avulsion.
Negative_regulation (reduced) of GAP in brachial plexus
1) Confidence 0.09 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC3017042 Disease Relevance 0 Pain Relevance 0.22
For example, when RGS2 was phosphorylated by PKC, GAP activity was reduced, then Gq/11 signals were enhanced [41]; RGS16 phosphorylation could also reduce its GAP activity toward GRi/o and result in increased adrenergic receptor signals [42], then the paralleled increase in RGS4 and PKA induced by brachial plexus avulsion will be expected to unmask their full functional potential, the orchestrated and dynamical RGS4 subcellular distribution and modulation will be the intriguing intracellular signal in response to brachial plexus avulsion.
Negative_regulation (reduce) of GAP in brachial plexus
2) Confidence 0.09 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC3017042 Disease Relevance 0 Pain Relevance 0.22
The activity of gap junctions is not only affected by altered expression or mutations in connexins but also secondary to changes of the adherens junction or the desmosome that can lead to mislocalization and loss of functional gap junctions (6, 7).
Negative_regulation (loss) of gap
3) Confidence 0.07 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556793 Disease Relevance 0.70 Pain Relevance 0
FoxO binds to an adjacent region near the GAP domain, thus inhibiting the GAP activity towards Rheb.


Negative_regulation (inhibiting) of GAP
4) Confidence 0.01 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.35 Pain Relevance 0

General Comments

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