INT247811

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Context Info
Confidence 0.34
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 9
Disease Relevance 2.61
Pain Relevance 1.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxadr) extracellular region (Cxadr) cell adhesion (Cxadr)
mitochondrion organization (Cxadr) plasma membrane (Cxadr) nucleus (Cxadr)
Anatomy Link Frequency
kidney 7
CAR 4
striatum 2
liver 1
muscle 1
Cxadr (Mus musculus)
Pain Link Frequency Relevance Heat
Substantia nigra 144 95.96 Very High Very High Very High
Dopamine 144 86.96 High High
isoflurane 9 86.32 High High
anesthesia 14 85.44 High High
addiction 17 82.48 Quite High
midbrain 24 75.24 Quite High
imagery 25 69.92 Quite High
Central nervous system 72 68.36 Quite High
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 259 99.88 Very High Very High Very High
Infection 34 93.04 High High
Embryonic Lethality 2 86.96 High High
Hypertrophy 1 73.44 Quite High
Parkinson's Disease 120 66.72 Quite High
Disease 15 48.20 Quite Low
Cytomegalovirus Infection 24 38.80 Quite Low
Arrhythmia Under Development 19 23.36 Low Low
Frailty 1 10.56 Low Low
Cancer 25 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that in these animals there was abundant expression of hCAR throughout the brain, with high abundance in both striatum and vMB (Figure 5A, B), and that the presence of this transgenic protein did not appreciably alter the expression of the endogenous mCAR.
Neg (not) Regulation (alter) of Gene_expression (expression) of mCAR in striatum associated with targeted disruption
1) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.56 Pain Relevance 0.15
Excision of exon 1, which contains the transcription and translation start, affects the expression of any CAR isoform, whereas the tight control of recombination by tamoxifen eliminates developmental effects that might arise from the embryonic loss of CAR expression.
Regulation (affects) of Gene_expression (expression) of CAR in CAR
2) Confidence 0.26 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556793 Disease Relevance 0.69 Pain Relevance 0
Transgenic mice express the human CAR gene lacking the cytoplasmic tail, under control of the human ubiquitin-C promoter, allowing hCAR to be expressed in a variety of tissues including the liver, kidney, heart, lungs, brain, and muscle [27].
Regulation (under) of Gene_expression (express) of CAR in kidney associated with targeted disruption
3) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.19 Pain Relevance 0.24
The expression of CAR in the nervous system and the role of this protein in targeting Ad5 vectors in the brain have not been closely examined [26], [27].
Regulation (role) of Gene_expression (expression) of CAR in CAR
4) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.22 Pain Relevance 0.15
Transgenic mice express the human CAR gene lacking the cytoplasmic tail, under control of the human ubiquitin-C promoter, allowing hCAR to be expressed in a variety of tissues including the liver, kidney, heart, lungs, brain, and muscle [27].
Regulation (under) of in liver Gene_expression (express) of CAR in kidney associated with targeted disruption
5) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.19 Pain Relevance 0.24
Transgenic mice express the human CAR gene lacking the cytoplasmic tail, under control of the human ubiquitin-C promoter, allowing hCAR to be expressed in a variety of tissues including the liver, kidney, heart, lungs, brain, and muscle [27].
Regulation (under) of in lungs Gene_expression (express) of CAR in kidney associated with targeted disruption
6) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.19 Pain Relevance 0.24
Transgenic mice express the human CAR gene lacking the cytoplasmic tail, under control of the human ubiquitin-C promoter, allowing hCAR to be expressed in a variety of tissues including the liver, kidney, heart, lungs, brain, and muscle [27].
Regulation (under) of in muscle Gene_expression (express) of CAR in kidney associated with targeted disruption
7) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.19 Pain Relevance 0.24
Transgenic mice express the human CAR gene lacking the cytoplasmic tail, under control of the human ubiquitin-C promoter, allowing hCAR to be expressed in a variety of tissues including the liver, kidney, heart, lungs, brain, and muscle [27].
Regulation (under) of in heart Gene_expression (express) of CAR in kidney associated with targeted disruption
8) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.19 Pain Relevance 0.24
Transgenic mice express the human CAR gene lacking the cytoplasmic tail, under control of the human ubiquitin-C promoter, allowing hCAR to be expressed in a variety of tissues including the liver, kidney, heart, lungs, brain, and muscle [27].
Regulation (under) of in brain Gene_expression (express) of CAR in kidney associated with targeted disruption
9) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.19 Pain Relevance 0.24

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