INT247855

Context Info Confidence 0.04 First Reported 2008 Last Reported 2008 Negated 0 Speculated 3 Reported most in Body Documents 1 Total Number 3 Disease Relevance 2.93 Pain Relevance 0.04

plasma membrane (Aqp4) protein complex (Aqp4) transmembrane transport (Aqp4) cytoplasm (Aqp4)

Anatomy Link Frequency retina 5 optic nerve 1 Narfl (Rattus norvegicus) Aqp4 (Rattus norvegicus)

Pain Link Frequency Relevance Heat glial activation 3 79.28 Neuritis 3 21.92 ketamine 6 5.00 anesthesia 6 5.00 ischemia 6 5.00 hyperexcitability 3 5.00 Demyelination 3 5.00

Disease Link Frequency Relevance Heat Ocular Hypertension 225 100.00 Glaucoma 54 97.84 Hypertrophy 24 96.52 Injury 36 96.12 Targeted Disruption 6 95.20 Stress 12 85.56 Ganglion Cysts 18 81.84 Neurodegenerative Disease 15 77.44 Low Tension Glaucoma 6 67.92 Neuromyelitis Optica 12 30.32

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the current study, elevation of IOP appears to affect AQP4 levels differently in the retina and ONH.

Positive_regulation (elevation) of IOP in retina Spec (appears) Regulation (affect) of AQP4 associated with ocular hypertension

1) Confidence 0.04 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 1.08 Pain Relevance 0.04

Increases in IOP appear also to affect AQP4 and ubiquitination levels distinctly in retina and optic nerve.

Positive_regulation (Increases) of IOP in retina Spec (appear) Regulation (affect) of AQP4 associated with ocular hypertension

2) Confidence 0.04 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.93 Pain Relevance 0

Increases in IOP appear also to affect AQP4 and ubiquitination levels distinctly in retina and optic nerve.

Positive_regulation (Increases) of IOP in retina Spec (appear) Regulation (affect) of in optic nerve AQP4 associated with ocular hypertension

3) Confidence 0.01 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.93 Pain Relevance 0

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