INT247856

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.00
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Uchl1) intracellular (Uchl1) ligase activity (Uchl1)
response to stress (Uchl1) cytoplasm (Uchl1) cell proliferation (Uchl1)
Anatomy Link Frequency
retina 4
Narfl (Rattus norvegicus)
Uchl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
hyperexcitability 2 62.80 Quite High
glial activation 2 21.36 Low Low
ischemia 4 6.00 Low Low
ketamine 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Demyelination 2 5.00 Very Low Very Low Very Low
Neuritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ocular Hypertension 150 100.00 Very High Very High Very High
Injury 24 76.08 Quite High
Aging 4 71.76 Quite High
Glaucoma 36 50.16 Quite High
Hypertrophy 16 12.16 Low Low
Low Tension Glaucoma 4 10.00 Low Low
Hypoxia 6 7.64 Low Low
Neurodegenerative Disease 10 6.64 Low Low
Cv Unclassified Under Development 4 6.00 Low Low
Ganglion Cysts 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Elevated IOP attenuated expression of UCH-L1 in retina as judged by Q-PCR (8 out 10 rats, 68±8%, p<0.005, Figure 10).
IOP Negative_regulation (attenuated) of Gene_expression (expression) of UCH-L1 in retina associated with ocular hypertension
1) Confidence 0.03 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.54 Pain Relevance 0
Elevated IOP decreased UCH-L1 mRNA levels in the retina, and this may also explain the increased ubiquitination in retina.
IOP Negative_regulation (decreased) of Gene_expression (levels) of UCH-L1 mRNA in retina associated with ocular hypertension
2) Confidence 0.03 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.45 Pain Relevance 0.03

General Comments

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