INT247861

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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.02
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Ube4a)
Anatomy Link Frequency
optic nerve 1
Ube4a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ketamine 6 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
ischemia 6 5.00 Very Low Very Low Very Low
hyperexcitability 3 5.00 Very Low Very Low Very Low
Demyelination 3 5.00 Very Low Very Low Very Low
Neuritis 3 5.00 Very Low Very Low Very Low
glial activation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ocular Hypertension 225 98.98 Very High Very High Very High
Hypertrophy 24 92.04 High High
Targeted Disruption 6 90.72 High High
Neurodegenerative Disease 15 84.88 Quite High
Stress 12 81.08 Quite High
Ganglion Cysts 18 77.36 Quite High
Glaucoma 54 76.56 Quite High
Injury 36 70.84 Quite High
Disease 9 29.96 Quite Low
Neuromyelitis Optica 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The decreased ubiquitination in axons may increase the levels of proapoptotic proteins normally degraded by the proteasome and thus contributes to axonal degeneration following elevated IOP.
Negative_regulation (decreased) of ubiquitination associated with ocular hypertension
1) Confidence 0.00 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.92 Pain Relevance 0
Western blot with anti-ubiquitin antibodies revealed a characteristic ubiquitin-positive smear in each lane corresponding to the amount of ubiquitination on proteins, and elevation of IOP enhanced ubiquitination in retinal extracts while decreased ubiquitination in optic nerve extracts (Figures 9A,B, respectively, n=10).
Negative_regulation (decreased) of ubiquitination in optic nerve associated with ocular hypertension
2) Confidence 0.00 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.37 Pain Relevance 0
Enhanced ubiquitination and decreased ubiquitination appear to correlate with AQP4 expression.
Negative_regulation (decreased) of ubiquitination
3) Confidence 0.00 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2559817 Disease Relevance 0.73 Pain Relevance 0

General Comments

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