INT247863

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.63
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Aqp4) protein complex (Aqp4) transmembrane transport (Aqp4)
cytoplasm (Aqp4)
Anatomy Link Frequency
retina 4
astrocytes 2
Aqp4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 8 99.16 Very High Very High Very High
hyperexcitability 3 94.16 High High
Neuritis 2 81.20 Quite High
glial activation 2 52.84 Quite High
anesthesia 5 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
Demyelination 2 5.00 Very Low Very Low Very Low
potassium channel 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 41 99.98 Very High Very High Very High
Hypoxia 11 99.98 Very High Very High Very High
Cv Unclassified Under Development 6 99.16 Very High Very High Very High
Ocular Hypertension 155 96.90 Very High Very High Very High
Neuromyelitis Optica 8 86.92 High High
Transverse Myelitis 2 82.16 Quite High
Optic Neuritis 2 81.20 Quite High
Glaucoma 47 80.64 Quite High
Autoimmune Disease 2 79.64 Quite High
Middle Cerebral Artery Infarction 2 77.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, AQP4 deletion in mice is neuroprotective in a transient ischemia model of retinal injury [37] and hypoxia induced a marked decrease in AQP4 mRNA levels in astrocytes in vitro [38], suggesting that the reduction of AQP4 levels may be a beneficial mechanism.
Positive_regulation (induced) of Negative_regulation (decrease) of AQP4 mRNA in astrocytes associated with hypoxia, ischemia and injury
1) Confidence 0.45 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 1.37 Pain Relevance 0.16
Therefore it is possible that the elevation of IOP would inhibit ubiquitin transport to axons and thus explain the attenuated ubiquitination in axons, whereas the accumulation of ubiquitin in retina could account for the enhanced ubiquitination and the downregulation of AQP4 protein.
Positive_regulation (account) of Negative_regulation (downregulation) of AQP4 protein in retina associated with ocular hypertension
2) Confidence 0.45 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.79 Pain Relevance 0
In the present study using the rat ONC model, we have shown for the first time that such injury causes a significant decrease in AQP4 and Kir4.1 protein and mRNA levels in retina, suggesting impaired ion homeostasis and K+ spatial buffering.
Positive_regulation (causes) of Negative_regulation (decrease) of AQP4 in retina associated with injury
3) Confidence 0.44 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.47 Pain Relevance 0.09

General Comments

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