INT247864

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.41
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Aqp4) protein complex (Aqp4) transmembrane transport (Aqp4)
cytoplasm (Aqp4)
Anatomy Link Frequency
retina 2
Aqp4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
glial activation 1 9.60 Low Low
ketamine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
hyperexcitability 1 5.00 Very Low Very Low Very Low
Demyelination 1 5.00 Very Low Very Low Very Low
Neuritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ocular Hypertension 75 97.84 Very High Very High Very High
Injury 12 64.32 Quite High
Glaucoma 18 38.40 Quite Low
Hypertrophy 8 10.60 Low Low
Ganglion Cysts 6 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 5 5.00 Very Low Very Low Very Low
Neuromyelitis Optica 4 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low
Hypoxia 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Enhanced ubiquitination may reflect accelerated degradation of proteins, including AQP4, which may explain the different effects of elevated IOP on AQP4 levels in retina versus optic nerve.
Positive_regulation (accelerated) of Protein_catabolism (degradation) of AQP4 in retina associated with ocular hypertension
1) Confidence 0.45 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.41 Pain Relevance 0

General Comments

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