INT247865

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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 10
Disease Relevance 9.22
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
eye 5
astrocytes 1
Narfl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 20 74.08 Quite High
ketamine 20 5.00 Very Low Very Low Very Low
ischemia 20 5.00 Very Low Very Low Very Low
hyperexcitability 10 5.00 Very Low Very Low Very Low
Demyelination 10 5.00 Very Low Very Low Very Low
Neuritis 10 5.00 Very Low Very Low Very Low
glial activation 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ocular Hypertension 750 100.00 Very High Very High Very High
Hypertrophy 80 98.88 Very High Very High Very High
Injury 120 97.92 Very High Very High Very High
Glaucoma 180 97.72 Very High Very High Very High
Disease 30 94.72 High High
Hypertension 10 93.80 High High
Ganglion Cysts 60 78.16 Quite High
Apoptosis 20 77.84 Quite High
Hypoxia 30 77.28 Quite High
Stress 40 70.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The enhanced expression of AQP4 in optic nerve astrocytes following elevation of IOP may explain the astrocytic hypertrophy normally seen in glaucoma patients and may involve alteration in the activity of ubiquitin-dependent proteasomal degradation system.
Gene_expression (expression) of IOP in astrocytes associated with hypertrophy, glaucoma and ocular hypertension
1) Confidence 0.09 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2559817 Disease Relevance 0.75 Pain Relevance 0
AUC measurements, yielding the IOP-integral difference of IOP elevation over days of exposure for treated eye and control eye, were calculated for each rat and represented as mmHg days.
Gene_expression (elevation) of IOP in eye associated with ocular hypertension
2) Confidence 0.09 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 1.31 Pain Relevance 0
Accordingly, IOP exposure for each rat was calculated by performing separate area-under curve (AUC) integration of IOP over the days of exposure for the treated and control eye.
Gene_expression (exposure) of IOP in eye associated with ocular hypertension
3) Confidence 0.09 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 1.35 Pain Relevance 0.07
Comparisons between groups of various mmHg days of IOP elevation were made using one-way ANOVA and multiple comparison tests at p <0.05.
Gene_expression (elevation) of IOP associated with ocular hypertension
4) Confidence 0.09 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 1.00 Pain Relevance 0.06
As shown in Figure 3A, nine out of 11 rats (82%, Figure 3A) showed a decrease in AQP4 protein levels in ET-1 injected eyes (70±10%, p<0.05) and AQP4 protein levels decreased in five out seven rats following elevation of IOP (71%; 72±12% p<0.001, 3C).
Gene_expression (elevation) of IOP in eyes associated with ocular hypertension
5) Confidence 0.09 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.99 Pain Relevance 0
A similar reduction was observed in AQP4 protein levels in ET-1 injected and IOP-elevated eyes.
Gene_expression (injected) of IOP in eyes associated with ocular hypertension
6) Confidence 0.09 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.93 Pain Relevance 0
AUC measurements, yielding the IOP-integral difference of IOP elevation over days of exposure for treated eye and control eye, were calculated for each rat and represented as mmHg days.
Gene_expression (elevation) of IOP in eye associated with ocular hypertension
7) Confidence 0.09 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 1.33 Pain Relevance 0
Also, similar to earlier reports [74–76] showing a reduction in thy-1 levels, elevation of IOP and intravitreal ET-1 injection resulted in decreased thy-1 levels (Figures 6A,B).
Gene_expression (injection) of IOP associated with ocular hypertension
8) Confidence 0.09 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.44 Pain Relevance 0
This study was designed to analyze changes in the expression of AQP4 following elevation of intraocular pressure (IOP) and after intravitreal endothelin-1 injection and the potential involvement of the ubiquitin-dependent proteasome.


Spec (analyze) Gene_expression (expression) of IOP associated with ocular hypertension
9) Confidence 0.08 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2559817 Disease Relevance 0.66 Pain Relevance 0
In the group with chronic elevated IOP, AQP4 expression was also seen in the three regions of the ONH.
Gene_expression (expression) of IOP associated with ocular hypertension
10) Confidence 0.05 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.45 Pain Relevance 0

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