INT247867

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Context Info
Confidence 0.11
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 5.16
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
optic nerve 2
Narfl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
glial activation 5 97.40 Very High Very High Very High
Neuritis 5 37.44 Quite Low
ketamine 10 5.00 Very Low Very Low Very Low
anesthesia 10 5.00 Very Low Very Low Very Low
ischemia 10 5.00 Very Low Very Low Very Low
hyperexcitability 5 5.00 Very Low Very Low Very Low
Demyelination 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ocular Hypertension 375 100.00 Very High Very High Very High
Glaucoma 90 94.28 High High
Apoptosis 10 90.00 High High
Hypertrophy 40 88.52 High High
Injury 60 88.24 High High
Gliosis 5 88.04 High High
Low Tension Glaucoma 10 83.44 Quite High
Targeted Disruption 10 65.44 Quite High
Stress 20 63.84 Quite High
Hypoxia 15 62.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tanihara et al. [60] have shown that elevation of IOP in primates was accompanied by increased GFAP mRNA and Yu et al. [61] observed elevation of IOP increased GFAP protein levels without significant changes in GFAP mRNA levels.
Positive_regulation (increased) of Positive_regulation (elevation) of IOP associated with ocular hypertension
1) Confidence 0.11 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 1.28 Pain Relevance 0
ET-1 injection also resulted in an increase in GFAP (Figure 4A, 380±100%, p<0.005) and similarly, elevation of IOP increased GFAP expression in all screened rats (133±10%, p<0.005, Figure 4B,C, n=6).
Positive_regulation (increased) of Positive_regulation (elevation) of IOP associated with ocular hypertension
2) Confidence 0.11 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.96 Pain Relevance 0
The present data are also in agreement with earlier studies that reported elevated IOP induced activation of caspase-3 [24,64–66].
Positive_regulation (elevated) of Positive_regulation (elevated) of IOP associated with ocular hypertension
3) Confidence 0.07 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.85 Pain Relevance 0
These observations suggest that IOP elevation is an important factor for increasing the levels of AQP4 and GFAP, which could promote glial activation at the optic nerve.
Positive_regulation (factor) of Positive_regulation (elevation) of IOP in optic nerve associated with ocular hypertension and glial activation
4) Confidence 0.07 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 1.23 Pain Relevance 0.05
The present data are also in agreement with earlier studies that reported elevated IOP induced activation of caspase-3 [24,64–66].
Positive_regulation (induced) of Positive_regulation (elevated) of IOP associated with ocular hypertension
5) Confidence 0.07 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.85 Pain Relevance 0

General Comments

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