INT247868

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Context Info
Confidence 0.11
First Reported 2008
Last Reported 2008
Negated 1
Speculated 2
Reported most in Body
Documents 1
Total Number 38
Disease Relevance 37.11
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
eye 7
retina 7
optic nerve 5
optic nerve head 2
astrocytes 2
Narfl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
glial activation 38 97.12 Very High Very High Very High
Demyelination 38 86.80 High High
Neuritis 38 85.76 High High
anesthesia 76 82.28 Quite High
ischemia 76 71.72 Quite High
hyperexcitability 38 67.16 Quite High
ketamine 76 48.20 Quite Low
Disease Link Frequency Relevance Heat
Ocular Hypertension 2850 100.00 Very High Very High Very High
Hypertrophy 304 99.88 Very High Very High Very High
Glaucoma 684 99.62 Very High Very High Very High
Injury 456 99.12 Very High Very High Very High
Hypertension 38 99.04 Very High Very High Very High
Neurodegenerative Disease 190 97.84 Very High Very High Very High
Congenital Anomalies 76 97.04 Very High Very High Very High
Low Tension Glaucoma 76 96.64 Very High Very High Very High
Ganglion Cysts 228 96.52 Very High Very High Very High
Disease 114 95.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tanihara et al. [60] have shown that elevation of IOP in primates was accompanied by increased GFAP mRNA and Yu et al. [61] observed elevation of IOP increased GFAP protein levels without significant changes in GFAP mRNA levels.
Positive_regulation (elevation) of IOP associated with ocular hypertension
1) Confidence 0.11 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 1.28 Pain Relevance 0
ET-1 injection also resulted in an increase in GFAP (Figure 4A, 380±100%, p<0.005) and similarly, elevation of IOP increased GFAP expression in all screened rats (133±10%, p<0.005, Figure 4B,C, n=6).
Positive_regulation (elevation) of IOP associated with ocular hypertension
2) Confidence 0.11 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.95 Pain Relevance 0
Tanihara et al. [60] have shown that elevation of IOP in primates was accompanied by increased GFAP mRNA and Yu et al. [61] observed elevation of IOP increased GFAP protein levels without significant changes in GFAP mRNA levels.
Positive_regulation (elevation) of IOP associated with ocular hypertension
3) Confidence 0.10 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 1.36 Pain Relevance 0
These observations suggest that IOP elevation is an important factor for increasing the levels of AQP4 and GFAP, which could promote glial activation at the optic nerve.
Positive_regulation (elevation) of IOP in optic nerve associated with ocular hypertension and glial activation
4) Confidence 0.10 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 1.21 Pain Relevance 0.05
The experimental glaucomatous eyes showed a significant and sustained increase in the IOP during the experimental period.
Positive_regulation (increase) of IOP in eyes associated with ocular hypertension
5) Confidence 0.10 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.63 Pain Relevance 0
The current finding that UCH-L1 mRNA levels are decreased with elevated IOP (Figure 10) is consistent with the findings in other neurodegenerative diseases.
Positive_regulation (elevated) of IOP associated with neurodegenerative disease and ocular hypertension
6) Confidence 0.10 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 1.21 Pain Relevance 0
Increased IOP appeared to enhance ubiquitination in the retina but decreased it in the optic nerve.
Positive_regulation (Increased) of IOP in retina associated with ocular hypertension
7) Confidence 0.10 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.39 Pain Relevance 0.03
Therefore it is possible that the elevation of IOP would inhibit ubiquitin transport to axons and thus explain the attenuated ubiquitination in axons, whereas the accumulation of ubiquitin in retina could account for the enhanced ubiquitination and the downregulation of AQP4 protein.
Spec (possible) Positive_regulation (elevation) of IOP in retina associated with ocular hypertension
8) Confidence 0.10 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.52 Pain Relevance 0
Increased GFAP labeling was similarly observed at the rat ONH exposed to elevated IOP as described by Johnson et al. [58] and Prasanna et al. [59].
Positive_regulation (elevated) of IOP associated with ocular hypertension
9) Confidence 0.10 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 1.44 Pain Relevance 0
Also, similar to earlier reports [74–76] showing a reduction in thy-1 levels, elevation of IOP and intravitreal ET-1 injection resulted in decreased thy-1 levels (Figures 6A,B).
Positive_regulation (elevation) of IOP associated with ocular hypertension
10) Confidence 0.10 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.38 Pain Relevance 0
The present data are also in agreement with earlier studies that reported elevated IOP induced activation of caspase-3 [24,64–66].
Positive_regulation (elevated) of IOP associated with ocular hypertension
11) Confidence 0.10 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.85 Pain Relevance 0
Increases in IOP appear also to affect AQP4 and ubiquitination levels distinctly in retina and optic nerve.
Positive_regulation (Increases) of IOP in retina associated with ocular hypertension
12) Confidence 0.10 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.92 Pain Relevance 0
Isotonic saline-injected (sham) rats, maintained for up to 140 days post-injection, showed no increase in IOP.
Neg (no) Positive_regulation (increase) of IOP associated with ocular hypertension
13) Confidence 0.10 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 1.37 Pain Relevance 0
Effect of intravitreal injection of ET-1 and elevated IOP on AQP4 in rat retinas
Positive_regulation (elevated) of IOP in retinas associated with ocular hypertension
14) Confidence 0.10 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 1.15 Pain Relevance 0
The decreased ubiquitination in axons may increase the levels of proapoptotic proteins normally degraded by the proteasome and thus contributes to axonal degeneration following elevated IOP.
Positive_regulation (elevated) of IOP associated with ocular hypertension
15) Confidence 0.10 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.90 Pain Relevance 0
The lack of selective AQP4 inhibitors also hampers a quicker evaluation of whether AQP4 inhibition will prevent hypertrophy upon elevation of IOP.
Spec (whether) Positive_regulation (elevation) of IOP associated with hypertrophy and ocular hypertension
16) Confidence 0.10 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 1.71 Pain Relevance 0.15
The enhanced expression of AQP4 in optic nerve astrocytes following elevation of IOP may explain the astrocytic hypertrophy normally seen in glaucoma patients and may involve alteration in the activity of ubiquitin-dependent proteasomal degradation system.
Positive_regulation (elevation) of IOP in astrocytes associated with hypertrophy, glaucoma and ocular hypertension
17) Confidence 0.07 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2559817 Disease Relevance 0.74 Pain Relevance 0
Fortune et al. [25] reported an estimated 6 mmHg difference between control and elevated IOP eyes following similar surgery.
Positive_regulation (elevated) of IOP in eyes associated with ocular hypertension
18) Confidence 0.07 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.95 Pain Relevance 0
As shown in Figure 1, IOP significantly increased in eyes with episcleral vein injection of hypertonic saline compared to the contralateral eyes and was maintained for up to 140 days post-surgery.
Positive_regulation (increased) of IOP in eyes associated with ocular hypertension
19) Confidence 0.07 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.43 Pain Relevance 0
IOP exposure is the cumulative IOP difference between the hypertensive (treated) eye to control (normotensive) eye and was calculated for each animal as mmHg days as previously described by McKinnon et al. [24].
Positive_regulation (cumulative) of IOP in eye associated with hypertension and ocular hypertension
20) Confidence 0.07 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 1.37 Pain Relevance 0.08

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