INT247870

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.00
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Aqp4) protein complex (Aqp4) transmembrane transport (Aqp4)
cytoplasm (Aqp4)
Aqp4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cva 12 95.72 Very High Very High Very High
potassium channel 1 66.40 Quite High
imagery 24 5.00 Very Low Very Low Very Low
ischemia 9 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Versed 3 5.00 Very Low Very Low Very Low
hyperexcitability 2 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Neuritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ocular Hypertension 80 99.84 Very High Very High Very High
Hydrocephalus 43 98.04 Very High Very High Very High
Intracranial Hypertension 7 96.00 Very High Very High Very High
Glaucoma 29 93.16 High High
Low Tension Glaucoma 3 92.64 High High
Hypertrophy 9 88.60 High High
Hypoxia 8 83.84 Quite High
Stress 8 47.96 Quite Low
Apoptosis 5 47.28 Quite Low
Injury 33 43.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our observation of decreased abundance of AQP4 in the periventricular region after two days of hydrocephalus coincide with symptoms indicative of raised intracranial pressure (ICP) as judged by clinical symptoms.
Negative_regulation (decreased) of Localization (abundance) of AQP4 associated with intracranial hypertension, hydrocephalus and cva
1) Confidence 0.43 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.70 Pain Relevance 0.21
Five out of 7 rats (71%) showed a significant reduction in mRNA (54±11%, p<0.001 versus HEPES-injected or control, Figure 2A), and there was a similar reduction in AQP4 mRNA upon elevation of IOP in six out nine rats (67%, 62±12, p=0.001, Figure 2B).
Negative_regulation (reduction) of Localization (elevation) of AQP4 mRNA associated with ocular hypertension
2) Confidence 0.41 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.94 Pain Relevance 0
As shown in Figure 2A, ONC resulted in a decrease in AQP4 protein (60±10, 63±10, and 38±10, p<0.001 at days 2, 7, and 14, respectively, Figure 2A,B, n=7), and there as a similar reduction in AQP4 mRNA (~40%), as determined by Q-PCR (61±5%, 60±8%, and 58±6 at days 2, 7, and 14, respectively, p<0.001 versus control, Figure 2B, n=7).
Negative_regulation (reduction) of Localization (decrease) of AQP4
3) Confidence 0.40 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.36 Pain Relevance 0.03

General Comments

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