INT247871

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.54
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 13
Disease Relevance 7.23
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Thy1) endoplasmic reticulum (Thy1) plasma membrane (Thy1)
enzyme binding (Thy1) cytoskeleton organization (Thy1)
Anatomy Link Frequency
retinas 2
ganglion cell 1
Thy1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 38 57.12 Quite High
glial activation 7 49.76 Quite Low
potassium channel 6 23.28 Low Low
anesthesia 20 5.00 Very Low Very Low Very Low
ketamine 14 5.00 Very Low Very Low Very Low
hyperexcitability 13 5.00 Very Low Very Low Very Low
Neuritis 7 5.00 Very Low Very Low Very Low
Demyelination 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 186 99.54 Very High Very High Very High
Ocular Hypertension 555 99.12 Very High Very High Very High
Ganglion Cysts 96 99.08 Very High Very High Very High
Stress 52 98.64 Very High Very High Very High
Hypertrophy 62 92.24 High High
Apoptosis 32 89.36 High High
Glaucoma 192 88.08 High High
Low Tension Glaucoma 20 85.12 High High
Gliosis 19 71.76 Quite High
Targeted Disruption 14 70.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When changes in thy-1 expression were compared to the time course of RGC cell loss, it is clear that a significant loss of thy-1 mRNA and protein occurs well in advance of RGC cell loss.
Negative_regulation (loss) of thy-1
1) Confidence 0.54 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.41 Pain Relevance 0
When changes in thy-1 expression were compared to the time course of RGC cell loss, it is clear that a significant loss of thy-1 mRNA and protein precedes RGC cell loss.
Negative_regulation (loss) of thy-1
2) Confidence 0.40 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 1.12 Pain Relevance 0.03
For example, while the RGC population decreased by approximately 47% at day 7, thy-1 mRNA decreased by 94%, showing that the reduction of thy-1 mRNA is much greater than the loss of RGCs.


Negative_regulation (reduction) of thy-1
3) Confidence 0.34 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.41 Pain Relevance 0
There was a reduction in thy-1 protein (94±18%, 33±6%, and 24±7% at days 2, 7, and 14, respectively, Figure 1D, p<0.005, n=7), although changes in thy-1 protein levels at day 2 were not statistically significant.
Negative_regulation (reduction) of thy-1
4) Confidence 0.34 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.18 Pain Relevance 0
For example, while the RGC population decreased by approximately 47% at day 7, thy-1 mRNA decreased by 94%, showing that the reduction of thy-1 mRNA is much greater than the loss of RGCs.


Negative_regulation (decreased) of thy-1
5) Confidence 0.34 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.40 Pain Relevance 0
In addition, ONC decreased thy-1 mRNA significantly (58±7% and 6±2%, days 2 and 7, respectively, p<0.001 versus sham, Figure 1E; data expressed as a ratio of the control value, n=8).
Negative_regulation (decreased) of thy-1
6) Confidence 0.34 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.16 Pain Relevance 0
Therefore, a reduction in thy-1 occurs in advance of detectable ganglion cell loss and both studies have suggested that thy-1 serves as an early marker of RGC stress but not a marker of RGC loss.
Negative_regulation (reduction) of thy-1 in ganglion cell associated with stress and ganglion cysts
7) Confidence 0.18 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.66 Pain Relevance 0
Both Huang et al. and Schlamp et al. [74,75] reported a reduction in thy-1 levels very early following IOP that preceded the actual reduction of RGC number.
Negative_regulation (reduction) of thy-1 associated with ocular hypertension
8) Confidence 0.18 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.60 Pain Relevance 0
Also, similar to earlier reports [74–76] showing a reduction in thy-1 levels, elevation of IOP and intravitreal ET-1 injection resulted in decreased thy-1 levels (Figures 6A,B).
Negative_regulation (reduction) of thy-1 associated with ocular hypertension
9) Confidence 0.18 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.42 Pain Relevance 0
In retinas of both injury models, there was an upregulation of GFAP (a marker of astrogliosis), caspase-3, and downregulation of thy-1, a marker for retinal ganglion cell stress, and decreased retinal AQP4 mRNA and protein levels as determined by Q-PCR, and western blotting, respectively.
Negative_regulation (downregulation) of thy-1 in retinas associated with stress, ganglion cysts and injury
10) Confidence 0.15 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2559817 Disease Relevance 0.88 Pain Relevance 0
By contrast, in both models, there was a reduction in thy-1 protein levels, a marker for RGC stress (Figure 6A,B, respectively, n=6; 75±10%, p<0.05 in both models).


Negative_regulation (reduction) of thy-1 associated with stress
11) Confidence 0.15 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.75 Pain Relevance 0
Overall, in both retinal injury models, both AQP4 and thy-1 levels were decreased in retinas.
Negative_regulation (decreased) of thy-1 in retinas associated with injury
12) Confidence 0.15 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.73 Pain Relevance 0
Also, similar to earlier reports [74–76] showing a reduction in thy-1 levels, elevation of IOP and intravitreal ET-1 injection resulted in decreased thy-1 levels (Figures 6A,B).
Negative_regulation (decreased) of thy-1 associated with ocular hypertension
13) Confidence 0.13 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.51 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox