INT247878

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.06
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.14
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
retina 3
optic nerve 1
Narfl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
hyperexcitability 3 67.16 Quite High
ischemia 6 10.36 Low Low
ketamine 6 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Demyelination 3 5.00 Very Low Very Low Very Low
Neuritis 3 5.00 Very Low Very Low Very Low
glial activation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ocular Hypertension 225 100.00 Very High Very High Very High
Neurodegenerative Disease 15 97.84 Very High Very High Very High
Ganglion Cysts 18 95.84 Very High Very High Very High
Diabetes Mellitus 3 95.20 Very High Very High Very High
Parkinson's Disease 3 94.48 High High
Glaucoma 54 86.36 High High
Aging 6 76.12 Quite High
Injury 36 74.88 Quite High
Gliosis 3 37.92 Quite Low
Hypertrophy 24 37.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore it is possible that the elevation of IOP would inhibit ubiquitin transport to axons and thus explain the attenuated ubiquitination in axons, whereas the accumulation of ubiquitin in retina could account for the enhanced ubiquitination and the downregulation of AQP4 protein.
Negative_regulation (inhibit) of Spec (possible) Positive_regulation (elevation) of IOP in retina associated with ocular hypertension
1) Confidence 0.06 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.52 Pain Relevance 0
Increased IOP appeared to enhance ubiquitination in the retina but decreased it in the optic nerve.
Negative_regulation (decreased) of in optic nerve Positive_regulation (Increased) of IOP in retina associated with ocular hypertension
2) Confidence 0.06 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.40 Pain Relevance 0.03
The current finding that UCH-L1 mRNA levels are decreased with elevated IOP (Figure 10) is consistent with the findings in other neurodegenerative diseases.
Negative_regulation (decreased) of Positive_regulation (elevated) of IOP associated with neurodegenerative disease and ocular hypertension
3) Confidence 0.06 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 1.21 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox