INT247880

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Context Info
Confidence 0.64
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.35
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Aqp4) protein complex (Aqp4) transmembrane transport (Aqp4)
cytoplasm (Aqp4)
Anatomy Link Frequency
retina 2
Aqp4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
glial activation 3 9.60 Low Low
ketamine 6 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
ischemia 6 5.00 Very Low Very Low Very Low
hyperexcitability 3 5.00 Very Low Very Low Very Low
Demyelination 3 5.00 Very Low Very Low Very Low
Neuritis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ocular Hypertension 225 97.84 Very High Very High Very High
Stress 12 87.60 High High
Ganglion Cysts 18 87.12 High High
Injury 36 81.52 Quite High
Hypertrophy 24 58.16 Quite High
Glaucoma 54 55.84 Quite High
Disease 9 40.64 Quite Low
Apoptosis 6 7.68 Low Low
Neurodegenerative Disease 15 5.00 Very Low Very Low Very Low
Neuromyelitis Optica 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Affinity purified ubiquitinated proteins on an S5a column from rat retinas revealed the presence of 87 and 100 kDa AQP4 high-molecular weight isoforms, suggesting that AQP4 is a target for degradation by the ubiquitin-dependent proteasome (Figure 8).
Protein_catabolism (degradation) of AQP4 in retinas
1) Confidence 0.64 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.13 Pain Relevance 0
Enhanced ubiquitination may reflect accelerated degradation of proteins, including AQP4, which may explain the different effects of elevated IOP on AQP4 levels in retina versus optic nerve.
Protein_catabolism (degradation) of AQP4 in retina associated with ocular hypertension
2) Confidence 0.64 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.41 Pain Relevance 0
AQP4 was detected in affinity-purified ubiquitinated proteins using S5a column, suggesting that AQP4 is a target for degradation by the ubiquitin-dependent proteasome.
Protein_catabolism (degradation) of AQP4
3) Confidence 0.64 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2559817 Disease Relevance 0.81 Pain Relevance 0

General Comments

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