INT247881

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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2008
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 3.69
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Ube4a)
Anatomy Link Frequency
optic nerve 2
retina 1
Ube4a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Demyelination 4 63.20 Quite High
ischemia 8 48.12 Quite Low
ketamine 8 5.00 Very Low Very Low Very Low
anesthesia 8 5.00 Very Low Very Low Very Low
hyperexcitability 4 5.00 Very Low Very Low Very Low
Neuritis 4 5.00 Very Low Very Low Very Low
glial activation 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ocular Hypertension 300 99.68 Very High Very High Very High
Injury 48 98.04 Very High Very High Very High
Hypertrophy 32 95.24 Very High Very High Very High
Targeted Disruption 8 93.92 High High
Apoptosis 8 89.08 High High
Stress 16 84.28 Quite High
Ganglion Cysts 24 80.56 Quite High
Neurodegenerative Disease 20 78.96 Quite High
Congenital Anomalies 8 73.44 Quite High
Disease 12 71.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using two models of retinal injuries: 1) intravitreal injection of ET-1; and 2) elevation of IOP according to the Morrison procedure, changes in AQP4 and ubiquitination levels were evaluated in retinal and optic nerve extracts.


Regulation (changes) of ubiquitination in optic nerve associated with injury and ocular hypertension
1) Confidence 0.00 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 1.02 Pain Relevance 0.03
Increases in IOP appear also to affect AQP4 and ubiquitination levels distinctly in retina and optic nerve.
Spec (appear) Regulation (affect) of ubiquitination in retina associated with ocular hypertension
2) Confidence 0.00 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.92 Pain Relevance 0
Changes in AQP4, caspase-3, thy-1, ubiquitination, and GFAP expression were also followed in total retinal extracts using western blotting.
Regulation (Changes) of ubiquitination
3) Confidence 0.00 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2559817 Disease Relevance 0.82 Pain Relevance 0
Increases in IOP appear also to affect AQP4 and ubiquitination levels distinctly in retina and optic nerve.
Spec (appear) Regulation (affect) of ubiquitination in optic nerve associated with ocular hypertension
4) Confidence 0.00 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.92 Pain Relevance 0

General Comments

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