INT247882

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.17
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Ube4a)
Anatomy Link Frequency
retina 2
optic nerve 1
Ube4a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 10 89.08 High High
hyperexcitability 3 59.68 Quite High
Substantia nigra 7 34.40 Quite Low
Inflammation 6 10.48 Low Low
ketamine 9 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
ischemia 6 5.00 Very Low Very Low Very Low
Demyelination 4 5.00 Very Low Very Low Very Low
Neuritis 3 5.00 Very Low Very Low Very Low
glial activation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ocular Hypertension 225 99.76 Very High Very High Very High
Stress 13 83.36 Quite High
Ganglion Cysts 18 82.88 Quite High
Glaucoma 54 77.52 Quite High
Injury 36 77.28 Quite High
Neurodegenerative Disease 24 70.24 Quite High
Aging 6 68.64 Quite High
Hypertrophy 24 66.16 Quite High
Parkinson's Disease 11 56.24 Quite High
Diabetes Mellitus 3 54.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of mildronate leads us to suggest that it is capable of regulating the ubiquitin proteasome pathway, probably by activating the proteasome and/or enhancing ubiquitination and thereby promoting protein degradation.
Positive_regulation (enhancing) of ubiquitination
1) Confidence 0.01 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC3000094 Disease Relevance 0.13 Pain Relevance 0.04
Therefore it is possible that the elevation of IOP would inhibit ubiquitin transport to axons and thus explain the attenuated ubiquitination in axons, whereas the accumulation of ubiquitin in retina could account for the enhanced ubiquitination and the downregulation of AQP4 protein.
Positive_regulation (enhanced) of ubiquitination in retina associated with ocular hypertension
2) Confidence 0.01 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.76 Pain Relevance 0
While elevation of IOP induced an increase in ubiquitination in retinal extracts, it decreased ubiquitination in optic nerve extracts as detected by western blotting.
Positive_regulation (increase) of ubiquitination in optic nerve associated with ocular hypertension
3) Confidence 0.01 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2559817 Disease Relevance 0.82 Pain Relevance 0
Elevated IOP decreased UCH-L1 mRNA levels in the retina, and this may also explain the increased ubiquitination in retina.
Positive_regulation (increased) of ubiquitination in retina associated with ocular hypertension
4) Confidence 0.01 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.45 Pain Relevance 0.03

General Comments

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