INT247883

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Context Info
Confidence 0.34
First Reported 2005
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.56
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Aqp3) transmembrane transport (Aqp3) cytoplasm (Aqp3)
Anatomy Link Frequency
duct 2
Aqp3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
hyperexcitability 1 97.32 Very High Very High Very High
antagonist 3 44.60 Quite Low
ischemia 2 40.52 Quite Low
Neuritis 1 23.40 Low Low
anesthesia 5 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
glial activation 1 5.00 Very Low Very Low Very Low
Demyelination 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 2 100.00 Very High Very High Very High
Chronic Renal Failure 124 99.44 Very High Very High Very High
Congenital Anomalies 3 51.76 Quite High
Ocular Hypertension 75 50.56 Quite High
Hypertrophy 19 47.60 Quite Low
Hypoxia 3 42.16 Quite Low
Injury 13 41.48 Quite Low
Cv Unclassified Under Development 2 40.52 Quite Low
Uremia 4 35.76 Quite Low
Neuromyelitis Optica 4 29.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the previous study (7), we found a marked reduction in the expression of two collecting duct water channels AQP2 and AQP3 in rats with CRF, indicating a defect in collecting duct water reabsorption.
Negative_regulation (reduction) of Gene_expression (expression) of AQP3 in duct associated with chronic renal failure
1) Confidence 0.34 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 0.31 Pain Relevance 0
In addition, the expression of several aquaporins including AQP1, AQP2, AQP3, and AQP5 decrease with aging [49–51], and therefore AQP4 expression may also decrease with aging.
Spec (may) Negative_regulation (decrease) of Gene_expression (expression) of AQP3 associated with aging
2) Confidence 0.23 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.25 Pain Relevance 0.05

General Comments

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