INT247918

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Context Info
Confidence 0.39
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.55
Pain Relevance 1.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc12a2)
Anatomy Link Frequency
spinal cord 4
Slc12a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 52 98.68 Very High Very High Very High
Pain 10 97.40 Very High Very High Very High
Neuropathic pain 36 97.04 Very High Very High Very High
antagonist 10 96.20 Very High Very High Very High
Hyperalgesia 28 91.80 High High
Thermal hyperalgesia 40 82.32 Quite High
GABAergic 16 81.16 Quite High
allodynia 6 76.24 Quite High
qutenza 6 75.52 Quite High
GABA receptor 4 66.24 Quite High
Disease Link Frequency Relevance Heat
Spinal Cord Injury 144 98.08 Very High Very High Very High
Contusions 8 97.92 Very High Very High Very High
Pain 10 97.40 Very High Very High Very High
Neuropathic Pain 52 97.04 Very High Very High Very High
Hyperalgesia 84 91.80 High High
Injury 24 63.76 Quite High
Pruritus 2 58.24 Quite High
Nociception 14 51.40 Quite High
Targeted Disruption 2 46.08 Quite Low
Nervous System Injury 8 45.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunoblotting showed a significant transient up-regulation of NKCC1 protein in epicenter of the rat spinal cord on day 14 post-SCI, which was accompanied by a concurrent down-regulation of KCC2 protein.
Positive_regulation (up) of Positive_regulation (regulation) of NKCC1 in spinal cord associated with spinal cord injury and spinal cord
1) Confidence 0.39 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 1.31 Pain Relevance 0.69
Immunoblotting showed a significant transient up-regulation of NKCC1 protein in the lesion epicenter of the rat spinal cord on day 14 post-SCI.
Positive_regulation (up) of Positive_regulation (regulation) of NKCC1 in spinal cord associated with spinal cord injury and spinal cord
2) Confidence 0.39 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 1.24 Pain Relevance 1.17

General Comments

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