INT247920

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Context Info
Confidence 0.51
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.90
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc12a5) intracellular (Slc12a5) transmembrane transport (Slc12a5)
Anatomy Link Frequency
neurons 2
Slc12a5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bDMF 10 96.56 Very High Very High Very High
Pain 5 91.28 High High
Spinal cord 26 74.80 Quite High
Neuronal excitability 2 69.68 Quite High
Limbic system 1 68.92 Quite High
Neuropathic pain 18 52.48 Quite High
GABAergic 13 47.44 Quite Low
antagonist 9 42.28 Quite Low
GABA receptor 3 38.80 Quite Low
Hyperalgesia 14 25.12 Quite Low
Disease Link Frequency Relevance Heat
Nervous System Injury 4 94.20 High High
Pain 5 91.28 High High
Stress 2 88.24 High High
Injury 14 80.52 Quite High
Nociception 7 77.08 Quite High
Spinal Cord Injury 72 72.00 Quite High
Neuropathic Pain 26 52.48 Quite High
Convulsion 30 50.00 Quite Low
Contusions 4 31.24 Quite Low
Hyperalgesia 42 25.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tyrosine phosphorylation of KCC2 by insulin-like growth factor (IGF-1) and tyrosine kinases increase its activity [144].
Positive_regulation (increase) of Phosphorylation (phosphorylation) of KCC2
1) Confidence 0.51 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645547 Disease Relevance 0.09 Pain Relevance 0.36
Exposing hippocampal neurons to H2O2 leads to a rapid dephosphorylation of KCC2 protein and a subsequent down-regulation of KCC2 protein [23].
Positive_regulation (leads) of Phosphorylation (dephosphorylation) of KCC2 protein in neurons
2) Confidence 0.45 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 0.81 Pain Relevance 0.27

General Comments

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