INT247921

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Context Info
Confidence 0.56
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.58
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc12a5) intracellular (Slc12a5) transmembrane transport (Slc12a5)
Anatomy Link Frequency
plasma 2
neurons 2
Slc12a5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 10 90.60 High High
Spinal cord 52 82.64 Quite High
Neuronal excitability 2 69.00 Quite High
Neuropathic pain 36 60.32 Quite High
GABAergic 16 46.76 Quite Low
GABA receptor 4 46.64 Quite Low
antagonist 10 41.60 Quite Low
Hyperalgesia 28 24.44 Low Low
allodynia 6 8.88 Low Low
qutenza 6 8.16 Low Low
Disease Link Frequency Relevance Heat
Nervous System Injury 8 93.52 High High
Pain 10 90.60 High High
Spinal Cord Injury 144 79.84 Quite High
Injury 24 79.84 Quite High
Nociception 14 76.40 Quite High
Neuropathic Pain 52 60.32 Quite High
Contusions 8 30.56 Quite Low
Hyperalgesia 84 24.44 Low Low
Peripheral Arterial Disease 10 5.00 Very Low Very Low Very Low
Hypersensitivity 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A loss of tyrosine phosphorylation of KCC2 and a reduction of surface-expression of KCC2 in the plasma membrane is largely attributable to tyrosine phosphatases [23].
Negative_regulation (loss) of Phosphorylation (phosphorylation) of KCC2 in plasma
1) Confidence 0.56 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 0.77 Pain Relevance 0.22
Exposing hippocampal neurons to H2O2 leads to a rapid dephosphorylation of KCC2 protein and a subsequent down-regulation of KCC2 protein [23].
Negative_regulation (regulation) of Phosphorylation (dephosphorylation) of KCC2 protein in neurons
2) Confidence 0.41 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 0.82 Pain Relevance 0.27

General Comments

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