INT247922

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Context Info
Confidence 0.79
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.42
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc12a5) intracellular (Slc12a5) transmembrane transport (Slc12a5)
Anatomy Link Frequency
plasma 2
neurons 1
Slc12a5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 78 97.08 Very High Very High Very High
bDMF 10 96.56 Very High Very High Very High
Pain 15 90.60 High High
Neuropathic pain 54 86.00 High High
GABA receptor 7 72.32 Quite High
Neuronal excitability 4 69.00 Quite High
Limbic system 1 68.92 Quite High
GABAergic 29 46.76 Quite Low
antagonist 19 41.60 Quite Low
Hyperalgesia 42 24.44 Low Low
Disease Link Frequency Relevance Heat
Spinal Cord Injury 216 98.16 Very High Very High Very High
Nervous System Injury 12 93.52 High High
Pain 15 90.60 High High
Neuropathic Pain 78 86.00 High High
Stress 2 82.80 Quite High
Injury 38 79.84 Quite High
Nociception 21 76.40 Quite High
Convulsion 30 50.00 Quite Low
Contusions 12 30.56 Quite Low
Hyperalgesia 126 24.44 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It remains to be determined whether altered KCC2 phosphorylation is responsible for translocation between the plasma membrane and intracellular compartments in SCI.
Spec (whether) Phosphorylation (phosphorylation) of KCC2 in plasma associated with spinal cord injury
1) Confidence 0.79 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 0.77 Pain Relevance 0.27
Exposing hippocampal neurons to H2O2 leads to a rapid dephosphorylation of KCC2 protein and a subsequent down-regulation of KCC2 protein [23].
Phosphorylation (dephosphorylation) of KCC2 protein in neurons
2) Confidence 0.79 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 0.81 Pain Relevance 0.27
A loss of tyrosine phosphorylation of KCC2 and a reduction of surface-expression of KCC2 in the plasma membrane is largely attributable to tyrosine phosphatases [23].
Phosphorylation (phosphorylation) of KCC2 in plasma
3) Confidence 0.79 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 0.76 Pain Relevance 0.22
Tyrosine phosphorylation of KCC2 by insulin-like growth factor (IGF-1) and tyrosine kinases increase its activity [144].
Phosphorylation (phosphorylation) of KCC2
4) Confidence 0.60 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645547 Disease Relevance 0.08 Pain Relevance 0.36

General Comments

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