INT247948

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Context Info
Confidence 0.26
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.16
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

embryo development (Cdk5r1, Cdk5) cytoplasm (Cdk5r1, Cdk5) nucleus (Cdk5r1, Cdk5)
plasma membrane (Cdk5r1, Cdk5) cell cycle (Cdk5r1, Cdk5) kinase activity (Cdk5r1, Cdk5)
Cdk5r1 (Mus musculus)
Cdk5 (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 14 69.44 Quite High
Eae 18 5.00 Very Low Very Low Very Low
Hippocampus 4 5.00 Very Low Very Low Very Low
amygdala 3 5.00 Very Low Very Low Very Low
Glutamate receptor 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
nMDA receptor 2 5.00 Very Low Very Low Very Low
medulla 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 1 94.00 High High
Cognitive Disorder 2 65.68 Quite High
Targeted Disruption 74 50.00 Quite Low
Anxiety Disorder 46 5.00 Very Low Very Low Very Low
Shock 7 5.00 Very Low Very Low Very Low
Post-traumatic Stress Disorder 5 5.00 Very Low Very Low Very Low
Body Weight 3 5.00 Very Low Very Low Very Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low
Congenital Anomalies 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For instance, the cyclin-dependent kinase 5 (Cdk5) activator, p35, is cleaved to p25 by calpain [3,4], and the generated p25 hyperactivates Cdk5, possibly leading to neurodegeneration.
Positive_regulation (generated) of p25 Spec (possibly) Positive_regulation (hyperactivates) of Cdk5
1) Confidence 0.26 Published 2008 Journal Mol Brain Section Body Doc Link PMC2561015 Disease Relevance 0.16 Pain Relevance 0.07

General Comments

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