INT247949

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Context Info
Confidence 0.26
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.12
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

embryo development (Cdk5r1, Cdk5) cytoplasm (Cdk5r1, Cdk5) nucleus (Cdk5r1, Cdk5)
plasma membrane (Cdk5r1, Cdk5) cell cycle (Cdk5r1, Cdk5) kinase activity (Cdk5r1, Cdk5)
Anatomy Link Frequency
brain 1
Cdk5r1 (Mus musculus)
Cdk5 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 24 99.92 Very High Very High Very High
Inflammation 4 77.72 Quite High
long-term potentiation 14 69.44 Quite High
Glutamate receptor 4 60.84 Quite High
Glutamate 1 59.60 Quite High
Eae 18 5.00 Very Low Very Low Very Low
Hippocampus 4 5.00 Very Low Very Low Very Low
amygdala 3 5.00 Very Low Very Low Very Low
nMDA receptor 2 5.00 Very Low Very Low Very Low
medulla 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 5 99.92 Very High Very High Very High
Death 25 97.48 Very High Very High Very High
Apoptosis 4 92.28 High High
INFLAMMATION 4 77.72 Quite High
Stroke 27 69.40 Quite High
Neurodegenerative Disease 1 66.72 Quite High
Cognitive Disorder 2 65.28 Quite High
Targeted Disruption 74 50.00 Quite Low
Injury 6 26.64 Quite Low
Cv Unclassified Under Development 14 18.56 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For instance, the cyclin-dependent kinase 5 (Cdk5) activator, p35, is cleaved to p25 by calpain [3,4], and the generated p25 hyperactivates Cdk5, possibly leading to neurodegeneration.
p25 Spec (possibly) Positive_regulation (hyperactivates) of Cdk5
1) Confidence 0.26 Published 2008 Journal Mol Brain Section Body Doc Link PMC2561015 Disease Relevance 0.16 Pain Relevance 0.07
CDK5 activity in the brain is triggered by its binding partners p39 and p35 [12].
p35 Positive_regulation (triggered) of CDK5 in brain
2) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920814 Disease Relevance 0.96 Pain Relevance 0.21

General Comments

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