INT24795

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Context Info
Confidence 0.51
First Reported 1980
Last Reported 2008
Negated 2
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 3.08
Pain Relevance 2.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
muscle 1
PNS 1
CII 1
mesangial cell 1
heart 1
Igh-6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 11 99.98 Very High Very High Very High
Peripheral nervous system 3 97.40 Very High Very High Very High
Neuritis 8 97.24 Very High Very High Very High
methadone 6 94.96 High High
addiction 1 93.76 High High
Arthritis 68 87.08 High High
spinal inflammation 1 84.88 Quite High
Inflammation 20 83.24 Quite High
methotrexate 41 81.52 Quite High
Angina 1 81.16 Quite High
Disease Link Frequency Relevance Heat
Coronary Artery Disease 2 99.52 Very High Very High Very High
Adhesions 1 99.04 Very High Very High Very High
Infection 3 97.96 Very High Very High Very High
Injury 4 97.36 Very High Very High Very High
Experimental Autoimmune Neuritis 8 97.24 Very High Very High Very High
Systemic Lupus Erythematosus 1 96.68 Very High Very High Very High
Autoimmune Disease 5 96.08 Very High Very High Very High
Opiate Addiction 1 94.04 High High
Myocardial Infarction 1 93.92 High High
Infarction 2 88.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Change in the immunoglobulin content in ischemic heart disease].
Regulation (Change) of immunoglobulin in heart associated with coronary artery disease
1) Confidence 0.51 Published 1980 Journal Kardiologiia Section Title Doc Link 7412084 Disease Relevance 0.55 Pain Relevance 0.08
On the other hand, the secondary IgG AFC response to KLH was enhanced by 10 pmoles BEP, while the IgM and IgA AFC responses remained unaltered by BEP treatment.
Regulation (unaltered) of IgM
2) Confidence 0.25 Published 1989 Journal Peptides Section Abstract Doc Link 2474158 Disease Relevance 0.09 Pain Relevance 0.14
Prolonged treatment with morphine, however, resulted in a decrease in host resistance to T. spiralis infection, as indicated by a 1.5-fold increase in numbers of muscle larvae counted in the carcass, but did not affect the T. spiralis-specific IgM, IgG and IgE antibody responses.
Neg (not) Regulation (affect) of IgM in muscle associated with infection and morphine
3) Confidence 0.22 Published 1998 Journal Toxicology Section Abstract Doc Link 9772098 Disease Relevance 0.16 Pain Relevance 0.97
More interestingly, T-614 not only suppressed CII antibody levels but also differentially modulated immunoglobulin subclass levels; these effects suggest that it may be useful for the treatment of lupus or other autoimmune disorders.
Regulation (modulated) of immunoglobulin in CII associated with autoimmune disease and systemic lupus erythematosus
4) Confidence 0.15 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656239 Disease Relevance 0.96 Pain Relevance 0.45
Our data suggest a pathogenic role of IgM antibodies against HNK adhesion carbohydrate epitope expressing PNS proteins P0, MAG and PMP-22.
Regulation (role) of IgM in PNS associated with peripheral nervous system and adhesions
5) Confidence 0.14 Published 1996 Journal J. Neuroimmunol. Section Abstract Doc Link 8982118 Disease Relevance 0.90 Pain Relevance 0.73
The serum anti-KLH IgG antibody titer decreased in the males of the IND 1.0 mg/kg dosing group, the serum levels of anti-KLH IgM, total IgM, and IgG were not changed at all.
Neg (not) Regulation (changed) of IgM
6) Confidence 0.11 Published 2007 Journal Toxicology Section Abstract Doc Link 17320264 Disease Relevance 0.05 Pain Relevance 0.21
Morphine modulates mesangial immunoglobulin G uptake in rats with antithymocyte serum-induced mesangial cell injury.
Regulation (modulates) of immunoglobulin in mesangial cell associated with injury and morphine
7) Confidence 0.09 Published 1996 Journal Nephron Section Title Doc Link 8883040 Disease Relevance 0.36 Pain Relevance 0.35

General Comments

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