INT247952

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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.32
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
muscle fibers 1
T cells 1
mononuclear cells 1
H2-K1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 41 87.52 High High
tolerance 6 81.12 Quite High
cytokine 8 77.04 Quite High
Central nervous system 28 60.20 Quite High
spinal inflammation 2 21.68 Low Low
psoriasis 4 19.52 Low Low
medulla 4 12.68 Low Low
anesthesia 3 5.00 Very Low Very Low Very Low
Inflammatory stimuli 3 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Respiratory Syncytial Virus 50 99.92 Very High Very High Very High
Influenza Virus Infection 28 99.00 Very High Very High Very High
Multiple Sclerosis 174 96.52 Very High Very High Very High
Infection 54 96.44 Very High Very High Very High
Disease 20 95.12 Very High Very High Very High
Recurrence 2 94.32 High High
Myositis 42 87.52 High High
Neurodegenerative Disease 2 81.36 Quite High
INFLAMMATION 35 76.24 Quite High
Autoimmune Disease 9 58.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, immunolabeling for Grp75 was not obligatorily related to the presence of sarcolemmal MHC-I immunoreactivity, in so far as it was detected also in those Group I and II patients who displayed MHC-I immunofluorescence only in a minor proportion of muscle fibers (grade +) (Figure 2k, l - arrows indicate MHC-I-positive fibers, arrowheads indicate negative fibers; compare with Figure 2i, j).
MHC-I-positive Binding (indicate) of in muscle fibers
1) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.34 Pain Relevance 0.07
On days 8 and 28 after infection, total pulmonary mononuclear cells (PMC) and total spleen mononuclear cells (SMC) were isolated [14] and were analyzed to quantify the number of CD8+ CTL that were positive for binding to the MHC class I tetramer (RSV M2-1) or pentamer (influenza virus NP) mentioned above, or for intracellular IFN?
MHC class I tetramer Binding (binding) of in mononuclear cells associated with influenza virus infection, respiratory syncytial virus and infection
2) Confidence 0.04 Published 2008 Journal Virol J Section Body Doc Link PMC2561024 Disease Relevance 1.35 Pain Relevance 0
This epitope bound the MHC–I (HLA-A*0201) with a relative good affinity (Fig.
MHC-I Binding (bound) of
3) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2823778 Disease Relevance 0.41 Pain Relevance 0.04
The antigen bound on Major Histocompatibility Complex class I (MHC-I) and presented to the T cell receptor (TCR) of CD8+ T cells, is normally produced by proteasomes.
MHC-I Binding (bound) of in T cells
4) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2823778 Disease Relevance 1.22 Pain Relevance 0.17

General Comments

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