INT247954

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Context Info
Confidence 0.16
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.97
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
lymphocytes 1
T-cells 1
Pdcd1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 75 99.84 Very High Very High Very High
Inflammation 256 99.56 Very High Very High Very High
Inflammatory response 18 78.88 Quite High
Arthritis 87 59.04 Quite High
cytokine 52 57.52 Quite High
chemokine 4 18.88 Low Low
Hippocampus 30 5.00 Very Low Very Low Very Low
imagery 20 5.00 Very Low Very Low Very Low
Pain 12 5.00 Very Low Very Low Very Low
agonist 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 24 99.88 Very High Very High Very High
Rheumatoid Arthritis 77 99.84 Very High Very High Very High
INFLAMMATION 275 99.56 Very High Very High Very High
Disease 75 97.68 Very High Very High Very High
Cyst 120 97.52 Very High Very High Very High
Viral Infection 3 97.36 Very High Very High Very High
Mycobacterial Infection 71 97.20 Very High Very High Very High
Infection 274 95.96 Very High Very High Very High
Toxoplasmosis 18 93.92 High High
Autoimmune Disease 20 90.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While this result suggests that tissue-specific up-regulation of PD-1 on the surface of pulmonary lymphocytes is not the mechanism for pulmonary T cell dysfunction, this does not rule out the possibility of differences in PD-1 ligand expression between the lung and spleen, nor any of the other mechanisms mentioned above.
Positive_regulation (regulation) of PD-1 in lymphocytes
1) Confidence 0.16 Published 2008 Journal Virol J Section Body Doc Link PMC2561024 Disease Relevance 0.38 Pain Relevance 0
A recent study shows that soluble programmed death one (PD-1) could be detected in RA patients and the levels of soluble PD-1 are correlated with TNF-?
Positive_regulation (detected) of PD-1 associated with rheumatoid arthritis and death
2) Confidence 0.11 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 1.23 Pain Relevance 0.36
The increase in PD-L1 (CD274) ligand, associated with "exhausted" T-cells in a chronic viral infection [86,109], may be a contributing factor that allows latency in chronic Toxoplasma infection, although other molecules may also play a role [110].
Positive_regulation (increase) of PD-L1 in T-cells associated with viral infection and toxoplasmosis
3) Confidence 0.04 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2588578 Disease Relevance 0.47 Pain Relevance 0.07
In the mice that received the anti-PD-1L there appeared to be an increased amount of inflammatory infiltrate relative to the numbers of cysts.


Positive_regulation (increased) of PD-1L associated with inflammation and cyst
4) Confidence 0.02 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2588578 Disease Relevance 1.03 Pain Relevance 0.16
and Th17 (IL-23/IL-17) responses related to increased CTLA-4 and PD-1 expression (manuscript in press).
Positive_regulation (increased) of PD-1
5) Confidence 0.01 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2710006 Disease Relevance 1.86 Pain Relevance 0.06

General Comments

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