INT247999

Context Info Confidence 0.06 First Reported 2008 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.75 Pain Relevance 0.35

plasma membrane (FXYD1)

FXYD1 (Homo sapiens)

Pain Link Frequency Relevance Heat Pain 10 96.80 anticonvulsant 1 81.64 Paresthesia 1 16.48 Dopamine 19 5.00 agonist 19 5.00 peripheral neuropathy 8 5.00 transdermal 6 5.00 Bioavailability 4 5.00 Eae 3 5.00 withdrawal 2 5.00

Disease Link Frequency Relevance Heat Restless Legs Syndrome 168 99.22 Pain 3 96.80 Akathisia 16 95.80 Sleep-wake Transition Disorders 1 95.28 Sleep Disorders 25 91.20 Leukemia 1 89.64 Hematological Disease 44 79.00 Cramps 2 75.12 Myoclonus 1 68.60 Death 3 61.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, similarly to RLS, dopaminergic agents are effective in decreasing PLM number.

Negative_regulation (decreasing) of PLM associated with restless legs syndrome

1) Confidence 0.06 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695234 Disease Relevance 1.19 Pain Relevance 0.35

54 of 54; 100%) were reduced in the ALM and PLM of the zTERT morphants (Figure 3A, a–f, a'–d') at 19 hpf, but almost recovered at the normal levels by 24 hpf (data not shown).

Negative_regulation (reduced) of PLM

2) Confidence 0.00 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2561060 Disease Relevance 0.57 Pain Relevance 0

General Comments

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