INT248
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Stimulation of GH release is a well-known effect of clonidine in man. | |||||||||||||||
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Nowadays, GHRPs are the most effective GH-secretagogues known and could be used profitably in humans with GH hyposecretory disturbances to promote a pattern of GH secretion that mimics physiology in a better way than the exogenously administered GH. | |||||||||||||||
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It is concluded that sumatriptan selectively increases GH secretion in man, but the exact nature of the receptors involved is not yet known. | |||||||||||||||
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After placebo pretreatment, clonidine (0.15 mg iv infused over 20 min) significantly stimulated GH secretion: the mean serum GH level rose from a basal level of 4.7 +/- 1.1 (+/- SEM) ng/ml to a maximum of 10.8 +/- 1.6 ng/ml (P less than 0.025). | |||||||||||||||
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Continuous GRF administration led to increased episodic GH secretion, by augmenting GH peak amplitude, although peak frequency was not modified. | |||||||||||||||
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Pretreatment with clonidine clearly changed the pattern of GH release during GRF infusion: the amount of GH secreted was significantly higher, the number of GH peaks significantly increased, and almost all the GH was secreted within them. | |||||||||||||||
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This indicates that alpha-adrenergic pathways stimulate GH secretion through a non-GRF-dependent mechanism in normal human subjects. | |||||||||||||||
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An absence of hypothalamic control was evident because clonidine did not stimulate GH release. | |||||||||||||||
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Clonidine, a central alpha-adrenergic agent and prophylactic antimigraine drug is known to stimulate human growth hormone (HGH) release and to suppress cortisol secretion. | |||||||||||||||
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Failure of naloxone to influence plasma growth hormone, prolactin, and cortisol secretions induced by insulin hypoglycemia. | |||||||||||||||
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This new stimulus showed a pattern similar to that of the hypothalamic stimuli, but clearly different with respect to the pituitary one (GHRH), suggesting that corticoids activate GH secretion by acting at hypothalamic level. | |||||||||||||||
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Corticoid-induced growth hormone (GH) secretion in GH-deficient and normal children. | |||||||||||||||
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It is well known that the acute administration of clonidine, an alpha 2-adrenergic agonist commonly used as an antihypertensive drug, stimulates GH secretion, likely via hypothalamic growth hormone releasing hormone (GHRH) release. | |||||||||||||||
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Atropine completely blocked exercise-induced GH secretion (2 +/- 0.9 ng/ml). | |||||||||||||||
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However, the evaluation of the physiological significance of D-induced GH release in humans requires further study. | |||||||||||||||
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Oral clonidine administration or insulin-induced hypoglycemia may enhance GH secretion through alpha 2-adrenergic stimulation in man. | |||||||||||||||
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GH secretion was significantly increased after 2 and 4 mg BS 100-141 and 0.30 mg clonidine. | |||||||||||||||
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However, the administration of hpGRF to both immature and adult birds made refractory to TRH challenge was followed by increased GH secretion and vice versa. | |||||||||||||||
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Cyproheptadine did not have any significant effect on dental pain threshold elevations, although it suppressed the exercise-induced GH release. | |||||||||||||||
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Paradoxically, the OGTT can stimulate GH secretion in about 10% of patients with acromegaly.
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General Comments
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