INT2480

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Context Info
Confidence 0.51
First Reported 1977
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 43
Total Number 43
Disease Relevance 14.47
Pain Relevance 16.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Got1) biosynthetic process (Got1) cellular amino acid metabolic process (Got1)
lysosome (Got1) cytoplasm (Got1)
Anatomy Link Frequency
body 3
liver 1
erythrocytes 1
hepatocytes 1
brain 1
Got1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 97 100.00 Very High Very High Very High
gABA 80 100.00 Very High Very High Very High
Glutamate 32 100.00 Very High Very High Very High
Gabapentin 6 99.74 Very High Very High Very High
Morphine 21 98.68 Very High Very High Very High
agonist 8 98.60 Very High Very High Very High
GABA receptor 1 98.44 Very High Very High Very High
cocaine 12 98.32 Very High Very High Very High
anesthesia 5 98.26 Very High Very High Very High
narcan 7 97.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hepatotoxicity 54 99.92 Very High Very High Very High
Body Weight 18 99.30 Very High Very High Very High
Gallstones 4 99.20 Very High Very High Very High
Cirrhosis 2 99.20 Very High Very High Very High
Oliguria 1 99.04 Very High Very High Very High
Cv Unclassified Under Development 2 98.52 Very High Very High Very High
Injury 41 97.84 Very High Very High Very High
Pleural Effusion 1 97.76 Very High Very High Very High
Depression 3 97.16 Very High Very High Very High
Shock 4 96.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Elevations of brain gamma-aminobutyric acid (GABA) induced by inhibitors of GABA transaminase (GABA-T) are known to induce a number of functional effects including depression of food intake.
Negative_regulation (inhibitors) of transaminase in brain associated with gaba and depression
1) Confidence 0.51 Published 1988 Journal Behav. Brain Res. Section Abstract Doc Link 2849456 Disease Relevance 0.21 Pain Relevance 0.43
The extract at an oral dose of 400 mg/kg exhibited a significant protective effect by lowering the serum levels of transaminase (SGOT and SGPT), bilirubin and alkaline phosphatase (ALP).
Negative_regulation (lowering) of transaminase
2) Confidence 0.43 Published 2000 Journal Phytother Res Section Abstract Doc Link 10960902 Disease Relevance 0.17 Pain Relevance 0.17
The quantity of acetaminophen ingested varied from 5 to 50 g and 19 patients developed raised transaminase levels in the serum during the initial period.
Negative_regulation (developed) of transaminase associated with paracetamol
3) Confidence 0.40 Published 1977 Journal Am J Dig Dis Section Abstract Doc Link 879126 Disease Relevance 0.40 Pain Relevance 0.40
However, simultaneous intubations of some of the rat with 10 mg or 20 mg mL(-1) of T. occidentalis leaf extract (free soluble or bound polyphenols) along side with the acetaminophen caused a significant decrease (p<0.05) in serum ALP, GOT and GPT (except those intubated with bound polyphenols).
Negative_regulation (decrease) of GOT in leaf associated with paracetamol
4) Confidence 0.39 Published 2007 Journal Pak. J. Biol. Sci. Section Abstract Doc Link 19070082 Disease Relevance 0.21 Pain Relevance 0.36
After treatment with W. chinensis (300 mg/kg, p.o.) at 2, 6 and 10 hours, a reduction in the elevation of serum glutamate oxaloacetic transaminase (SGOT) and glutamate pyruvic transaminase (SGPT) levels was observed at 24 hrs after hepatotoxins were administered.
Negative_regulation (reduction) of transaminase associated with glutamate
5) Confidence 0.37 Published 1994 Journal Am. J. Chin. Med. Section Abstract Doc Link 7992815 Disease Relevance 0.17 Pain Relevance 0.20
After treatment with W. chinensis (300 mg/kg, p.o.) at 2, 6 and 10 hours, a reduction in the elevation of serum glutamate oxaloacetic transaminase (SGOT) and glutamate pyruvic transaminase (SGPT) levels was observed at 24 hrs after hepatotoxins were administered.
Negative_regulation (reduction) of transaminase associated with glutamate
6) Confidence 0.37 Published 1994 Journal Am. J. Chin. Med. Section Abstract Doc Link 7992815 Disease Relevance 0.17 Pain Relevance 0.20
Anesthesia with deuterated chloroform at a concentration of 0.36 per cent produced a 35 per cent decrease in serum glutamic pyruvic transaminase (SGPT).
Negative_regulation (decrease) of transaminase associated with anesthesia
7) Confidence 0.37 Published 1979 Journal Anesthesiology Section Abstract Doc Link 453609 Disease Relevance 0 Pain Relevance 0.14
The basal specific activities (S.A.; mumol of pyruvate/hr/10(8) erythrocytes) and the % deficiencies of activity of the glutamic oxaloacetic transaminase of the erythrocytes (EGOT) of 174 university students was 0.28 +/- 0.05 and 33 +/- 9%, respectively.
Negative_regulation (deficiencies) of transaminase in erythrocytes
8) Confidence 0.35 Published 1981 Journal J. Nutr. Sci. Vitaminol. Section Abstract Doc Link 7288513 Disease Relevance 0.07 Pain Relevance 0.07
Whole tissue extract of Lampito mauritii protect the paracetamol (2 g/kg body weight. p.o.) induced liver damage rat as a dose dependent manner (100, 200 and 300 mg/kg body weight p.o.) by significantly (P < 0.05) decreasing the hepatic marker enzymes--aspartate transaminase, alanine transaminase and alkaline phosphatase similar to silymarin (150 mg/kg b.w. p.o.).
Negative_regulation (decreasing) of transaminase in body associated with paracetamol, body weight and hepatotoxicity
9) Confidence 0.34 Published 2007 Journal Eur Rev Med Pharmacol Sci Section Abstract Doc Link 18306909 Disease Relevance 0.38 Pain Relevance 0.22
Whole tissue extract of Lampito mauritii protect the paracetamol (2 g/kg body weight. p.o.) induced liver damage rat as a dose dependent manner (100, 200 and 300 mg/kg body weight p.o.) by significantly (P < 0.05) decreasing the hepatic marker enzymes--aspartate transaminase, alanine transaminase and alkaline phosphatase similar to silymarin (150 mg/kg b.w. p.o.).
Negative_regulation (decreasing) of transaminase in body associated with paracetamol, body weight and hepatotoxicity
10) Confidence 0.34 Published 2007 Journal Eur Rev Med Pharmacol Sci Section Abstract Doc Link 18306909 Disease Relevance 0.38 Pain Relevance 0.22
The influence of a GABA transaminase inhibitor, gamma-vinyl GABA, on voluntary morphine consumption in the rat.
Negative_regulation (inhibitor) of transaminase associated with gaba and morphine
11) Confidence 0.33 Published 1981 Journal Psychopharmacology (Berl.) Section Title Doc Link 6798609 Disease Relevance 0.17 Pain Relevance 1.00
Pretreatment of rats with plant extract (500 mg/kg) significantly lowered (P < 0.05) the respective serum ALP; GOT and GPT levels to 192 +/- 31, 63 +/- 9 and 35 +/- 8. 5.
Negative_regulation (lowered) of GOT
12) Confidence 0.33 Published 1995 Journal Gen. Pharmacol. Section Abstract Doc Link 7789738 Disease Relevance 0.24 Pain Relevance 0.40
Pretreatment of rats with plant extract (150 mg/kg) lowered significantly the respective serum GOT and GPT levels to 85 +/- 11 and 23 +/- 06. 5.
Negative_regulation (lowered) of GOT
13) Confidence 0.33 Published 1993 Journal Gen. Pharmacol. Section Abstract Doc Link 8112519 Disease Relevance 0.25 Pain Relevance 0.33
Pretreatment of rats with the plant extract (500 mg/kg) lowered significantly (P < 0.001) the respective serum GOT and GPT levels to 112 +/- 10 I.U.
Negative_regulation (lowered) of GOT
14) Confidence 0.32 Published 1995 Journal J Ethnopharmacol Section Abstract Doc Link 7564420 Disease Relevance 0.24 Pain Relevance 0.47
To substantiate the notion that cocaine behavioral effects may be influenced by gamma-aminobutyric acid (GABA) neurotransmission male Wistar rats were injected with gabapentin (a cyclic GABA analogue), tiagabine (a GABA reuptake inhibitor), or vigabatrin (a GABA transaminase inhibitor) before acute or repeated treatment with cocaine evoking either locomotor hyperactivation or sensitization.
Negative_regulation (inhibitor) of transaminase associated with gaba, gabapentin and cocaine
15) Confidence 0.32 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16777090 Disease Relevance 0 Pain Relevance 0.75
One method was based on the irreversible inhibition of GABA transaminase (EC 2.6.1.19) by microinjection of gamma-vinyl-GABA into neostriatum of rat.
Negative_regulation (inhibition) of transaminase associated with gaba
16) Confidence 0.31 Published 1987 Journal Biochem. Pharmacol. Section Abstract Doc Link 3555508 Disease Relevance 0.07 Pain Relevance 0.46
The neuropathological, biochemical, and behavioral effects of intrastriatal injection of aminooxyacetic acid (AOAA), a non-specific transaminase inhibitor, were examined in rats.
Negative_regulation (inhibitor) of transaminase
17) Confidence 0.29 Published 1991 Journal Synapse Section Abstract Doc Link 1821484 Disease Relevance 0 Pain Relevance 0.09
Neither tiagabine (2.5 mg/kg, i.p.; a GABA reuptake inhibitor), vigabatrin (75-150 mg/kg, i.p.; an irreversible inhibitor of GABA transaminase), nor baclofen (0.5 mg/kg, i.p.; a GABA(B) receptor agonist) substituted for heroin.
Negative_regulation (inhibitor) of transaminase associated with gaba and agonist
18) Confidence 0.27 Published 2005 Journal Pharmacol Rep Section Abstract Doc Link 16382192 Disease Relevance 0 Pain Relevance 0.75
KEY FINDINGS: Levels of serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase and alkaline phosphatases, which were increased in the serum, were found to be significantly reduced by the treatment of lutein in a dose-dependent manner, indicating that lutein may reduce the hepatotoxicity induced by these agents(. )Serum bilirubin was also significantly lower in lutein-treated groups compared with control.
Negative_regulation (reduced) of transaminase
19) Confidence 0.26 Published 2010 Journal J. Pharm. Pharmacol. Section Body Doc Link 20663040 Disease Relevance 0 Pain Relevance 0
Results showed that CHCKT treatments significantly decreased the level of serum glutamic oxaloacetic transaminase (sGOT) and glutamic pyruvic transaminase (sGPT) in APAP-treated groups.
Negative_regulation (decreased) of serum glutamic oxaloacetic transaminase associated with paracetamol
20) Confidence 0.22 Published 2007 Journal Am. J. Chin. Med. Section Abstract Doc Link 17265552 Disease Relevance 0.43 Pain Relevance 0.43

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