INT248001

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Context Info
Confidence 0.49
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.51
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood cell 6
erythroblasts 2
SNORA73A (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 144 100.00 Very High Very High Very High
Cleidocranial Dysplasia 8 98.12 Very High Very High Very High
Hematological Disease 176 95.40 Very High Very High Very High
Anaemia 40 94.44 High High
Pancytopenia 28 83.80 Quite High
Congenital Anomalies 24 77.04 Quite High
Disease 8 52.80 Quite High
Myelodysplastic Syndromes 24 51.04 Quite High
Targeted Disruption 60 5.00 Very Low Very Low Very Low
Aplastic Anemia 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Induced p53 deficiency, as well as overexpression of the anti-apoptotic proteins Bcl-2 and E1B-19K, significantly relieves the decreased blood cells numbers caused by zTERT knockdown, but not the impaired blood cell differentiation.
Positive_regulation (Induced) of Gene_expression (overexpression) of E1B in blood cell associated with apoptosis
1) Confidence 0.49 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2561060 Disease Relevance 0.62 Pain Relevance 0
Induced p53 deficiency, as well as overexpression of the anti-apoptotic proteins Bcl-2 and E1B-19K, significantly relieves the decreased blood cells numbers caused by zTERT knockdown, but not the impaired blood cell differentiation.
Positive_regulation (overexpression) of Gene_expression (overexpression) of E1B in blood cell associated with apoptosis
2) Confidence 0.49 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2561060 Disease Relevance 0.61 Pain Relevance 0
However, neither Bcl-2, E1B-19K overexpression, nor p53 deficiency, could restore blood cell dysplasia, which was evidenced by the presence of immature erythrocytes (erythroblasts) and anemia (data not shown for Bcl-2 and E1B-19K).
Neg (neither) Positive_regulation (overexpression) of Gene_expression (overexpression) of E1B in erythroblasts associated with anaemia and cleidocranial dysplasia
3) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2561060 Disease Relevance 0.59 Pain Relevance 0
The overexpression of Bcl-2 or E1B-19K was also found to counteract the reduction in the number of blood cells due to cytopenia.
Positive_regulation (overexpression) of Gene_expression (overexpression) of E1B in blood cells
4) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2561060 Disease Relevance 0.69 Pain Relevance 0

General Comments

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