INT248076

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.47
First Reported 2008
Last Reported 2008
Negated 3
Speculated 0
Reported most in Body
Documents 1
Total Number 13
Disease Relevance 2.24
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (SLC2A9) plasma membrane (SLC2A9) transmembrane transport (SLC2A9)
Anatomy Link Frequency
blood 3
SLC2A9 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 13 36.72 Quite Low
Disease Link Frequency Relevance Heat
Hypertension 273 100.00 Very High Very High Very High
Cardiovascular Disease 39 97.64 Very High Very High Very High
Obesity 65 96.72 Very High Very High Very High
Crystal Associated Disease 169 96.52 Very High Very High Very High
Diabetes Mellitus 117 96.28 Very High Very High Very High
Metabolic Syndrome 65 95.88 Very High Very High Very High
Aging 65 92.16 High High
Hypoglycemia 52 90.16 High High
Disease 26 70.32 Quite High
Arthritis 13 46.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, we did not find any evaluated association of the same SLC2A9 SNP with hypertension under an additive model in 5,249 hypertensive cases and 6,648 normotensive controls drawn from all the studies.
SLC2A9 Neg (not) Binding (association) of associated with hypertension
1) Confidence 0.47 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2561076 Disease Relevance 0.28 Pain Relevance 0
The two SNPs genotyped in the Olivetti cohort validate association of the SLC2A9 locus with serum urate and demonstrate the association of both SNPs with reduced urinary urate excretion at two time points 8 y apart.
SLC2A9 Binding (association) of
2) Confidence 0.47 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2561076 Disease Relevance 0.08 Pain Relevance 0
For reporting our results here we focus upon the additive model for all cohort analyses, because the association of SLC2A9 SNPs with serum urate is best described by this model [7].
SLC2A9 Binding (association) of
3) Confidence 0.37 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2561076 Disease Relevance 0.09 Pain Relevance 0
Association Studies of the SLC2A9 Gene with Blood Pressure
SLC2A9 Gene Binding (Association) of in Blood
4) Confidence 0.37 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2561076 Disease Relevance 0.10 Pain Relevance 0
Confirmation of SLC2A9-Mediated Urate Transport in a Second Mammalian Cell Line
SLC2A9 Binding (Confirmation) of
5) Confidence 0.37 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2561076 Disease Relevance 0.09 Pain Relevance 0
Association Studies of the SLC2A9 Gene with Hypertension
SLC2A9 Gene Binding (Association) of associated with hypertension
6) Confidence 0.37 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2561076 Disease Relevance 0.22 Pain Relevance 0
We did not find an association of the SLC2A9 gene with blood pressure in this study.
SLC2A9 gene Neg (not) Binding (association) of in blood
7) Confidence 0.35 Published 2008 Journal PLoS Medicine Section Abstract Doc Link PMC2561076 Disease Relevance 0.16 Pain Relevance 0
We used data from the Olivetti Heart Study to test association of SLC2A9 variants and fractional urate excretion, and then tested for association with blood pressure and hypertension in additional cohorts.


SLC2A9 Binding (association) of in blood associated with hypertension
8) Confidence 0.35 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2561076 Disease Relevance 0.10 Pain Relevance 0
Association of SLC2A9 Gene Variants with Serum and Fractional Excretion of Urate
SLC2A9 Gene Binding (Association) of
9) Confidence 0.35 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2561076 Disease Relevance 0 Pain Relevance 0
In this paper we have translated the genetic association of the SLC2A9 locus with serum urate derived from genome-wide scanning into a functional confirmation that SLC2A9 splice variants acts as a high-capacity urate transporter that can be facilitated by exchange with hexoses and inhibited by high concentrations of some uricosurics and siRNA technology.
SLC2A9 Binding (association) of
10) Confidence 0.35 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2561076 Disease Relevance 0.64 Pain Relevance 0
In order to test the specificity of SLC2A9a and SLC2A9b for urate, non-radiolabelled urate was added to the uptake assay at a final concentration of 1 mM.
SLC2A9b Binding (specificity) of
11) Confidence 0.35 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2561076 Disease Relevance 0.07 Pain Relevance 0
In order to test the specificity of SLC2A9a and SLC2A9b for urate, non-radiolabelled urate was added to the uptake assay at a final concentration of 1 mM.
SLC2A9a Binding (specificity) of
12) Confidence 0.35 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2561076 Disease Relevance 0.07 Pain Relevance 0
The results of our meta-analysis combining six caseĀ–control studies (see Table 4) did not show a significant association between hypertension and the SLC2A9 variant tested (odds ratio 0.98, 95% CI 0.91 to 1.05, p > 0.6).


SLC2A9 Neg (not) Binding (association) of associated with hypertension
13) Confidence 0.32 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2561076 Disease Relevance 0.35 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox