INT248112

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Context Info
Confidence 0.75
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 13
Disease Relevance 4.78
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (FABP2) cytoplasm (FABP2)
Anatomy Link Frequency
plasma 5
blood 2
large intestine 2
enterocyte 1
lamina 1
FABP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 112 93.04 High High
Inflammation 28 85.08 High High
Bile 11 78.72 Quite High
Inflammatory response 45 52.84 Quite High
Spinal cord 11 5.00 Very Low Very Low Very Low
Analgesic 11 5.00 Very Low Very Low Very Low
Morphine 11 5.00 Very Low Very Low Very Low
Paracetamol 11 5.00 Very Low Very Low Very Low
Opioid 11 5.00 Very Low Very Low Very Low
Chronic pancreatitis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pressure Volume 2 Under Development 275 98.12 Very High Very High Very High
Cv Unclassified Under Development 87 93.04 High High
Multiple Organ Failure 46 86.76 High High
Systemic Inflammatory Response Syndrome 35 86.44 High High
Cv General 4 Under Development 25 85.76 High High
INFLAMMATION 60 85.08 High High
Apoptosis 40 80.28 Quite High
Death 45 77.32 Quite High
Sepsis 24 76.72 Quite High
Injury 102 75.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, plasma levels of I-FABP, I-BABP were significantly negatively correlated with MAP at ½ hour before blood sampling (correlation: ?
Gene_expression (levels) of I-FABP in plasma
1) Confidence 0.75 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2599890 Disease Relevance 0.29 Pain Relevance 0
Plasma levels of I-FABP, I-BABP were significantly negatively correlated with MAP at ½ hour before blood sampling (?
Gene_expression (levels) of I-FABP in blood
2) Confidence 0.75 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2599890 Disease Relevance 0.26 Pain Relevance 0
Furthermore, circulating values of I-FABP correlated with gastric mucosal PrCO2 and Pr-aCO2-gap measured at the same time points (correlation: 0.553 (p?
Gene_expression (values) of I-FABP
3) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2599890 Disease Relevance 0.59 Pain Relevance 0
Thirteen patients showed an increase in plasma I-FABP levels of at least twofold during surgery; while 7 patients had relatively unchanged circulating I-FABP values.
Gene_expression (levels) of I-FABP in plasma
4) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2599890 Disease Relevance 0.19 Pain Relevance 0
Similar to the I-FABP levels, mean I-BABP plasma concentrations also increased significantly between 2 and 8 hours after start of surgery compared to baseline values in most of the patients (Figure 1b).
Gene_expression (levels) of I-FABP in plasma
5) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2599890 Disease Relevance 0.26 Pain Relevance 0
Thirteen patients showed an increase in plasma I-FABP levels of at least twofold during surgery; while 7 patients had relatively unchanged circulating I-FABP values.
Gene_expression (values) of I-FABP in plasma
6) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2599890 Disease Relevance 0.19 Pain Relevance 0
The cells coating the lamina propria were immunopositive for I-FABP and ZO-1, indicating that the epithelial continuity contained viable enterocytes with intact tight junctions (Figure 2D).
Gene_expression (immunopositive) of I-FABP in lamina
7) Confidence 0.60 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2561292 Disease Relevance 0.37 Pain Relevance 0.08
Immediately after the start of the reperfusion, the I-FABP staining of the subepithelial space strongly indicates a loss of enterocyte membrane integrity, resulting in leakage of I-FABP into the subepithelial space.
Gene_expression (staining) of I-FABP in enterocyte
8) Confidence 0.60 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2561292 Disease Relevance 0.48 Pain Relevance 0.18
Plasma concentration of I-FABP, I-BABP and urinary expression of claudin-3 increased rapidly and significantly after the onset of surgery in most children.
Gene_expression (expression) of I-FABP in Plasma
9) Confidence 0.58 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2599890 Disease Relevance 0.23 Pain Relevance 0
Our work is supported by three previous studies showing the temporary presence of intestinal villous cell damage, measured by increased urinary levels of I-FABP, in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB) [29]–[31].
Gene_expression (levels) of I-FABP
10) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2599890 Disease Relevance 0.99 Pain Relevance 0.11
To this end within-person correlations were studied between circulating levels of I-FABP, I-BABP and intraoperative MAP at ½ hour before the blood sample was collected in which FABP concentration was measured, and PrCO2, Pr-aCO2-gap at the same moment of blood sampling.
Gene_expression (levels) of I-FABP in blood
11) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2599890 Disease Relevance 0.30 Pain Relevance 0
Enterocyte damage was assessed using plasma levels of Intestinal-Fatty Acid Binding Protein (I-FABP), a small cytosolic, water-soluble protein, primarily limited to mature enterocytes of small and large intestine [20].
Gene_expression (levels) of I-FABP in large intestine
12) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2599890 Disease Relevance 0.34 Pain Relevance 0.11
Enterocyte damage was assessed using plasma levels of Intestinal-Fatty Acid Binding Protein (I-FABP), a small cytosolic, water-soluble protein, primarily limited to mature enterocytes of small and large intestine [20].
Gene_expression (levels) of Intestinal-Fatty Acid Binding Protein in large intestine
13) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2599890 Disease Relevance 0.29 Pain Relevance 0.11

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