INT24813

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Context Info
Confidence 0.16
First Reported 1986
Last Reported 2006
Negated 0
Speculated 1
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 1.30
Pain Relevance 4.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Trib3) nucleus (Trib3) enzyme binding (Trib3)
kinase activity (Trib3)
Anatomy Link Frequency
striatum 2
lung 2
hearts 2
Trib3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 5 100.00 Very High Very High Very High
Desipramine 8 99.40 Very High Very High Very High
agonist 4 98.90 Very High Very High Very High
Endep 14 98.28 Very High Very High Very High
Inflammation 15 97.52 Very High Very High Very High
medulla 3 96.92 Very High Very High Very High
Kinase C inhibitor 3 96.04 Very High Very High Very High
antidepressant 20 93.44 High High
butorphanol 4 90.64 High High
fluoxetine 3 90.28 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 21 97.52 Very High Very High Very High
Colon Cancer 1 95.52 Very High Very High Very High
Bordatella Infection 1 94.16 High High
Pheochromocytoma 1 93.32 High High
Drug Dependence 4 88.72 High High
Nociception 1 86.16 High High
Hyperalgesia 1 79.24 Quite High
Glioblastoma 4 76.64 Quite High
Opiate Addiction 1 58.60 Quite High
Body Weight 5 48.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using activity ratios to judge the extent of activation of cAMP-dependent protein kinase in vivo, it was found that isoproterenol-induced increases in cAMP protein kinase activity were similar in control and acutely-treated animals, but were reduced with repeated desipramine treatment.
Negative_regulation (reduced) of Positive_regulation (increases) of kinase associated with desipramine
1) Confidence 0.16 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2937646 Disease Relevance 0 Pain Relevance 0.55
Furthermore, concomitant infusion of H-7 inhibited the enhancement of protein kinase C activity.
Negative_regulation (inhibited) of Positive_regulation (enhancement) of kinase associated with kinase c
2) Confidence 0.14 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8549612 Disease Relevance 0.30 Pain Relevance 1.63
Exposure of arrested hearts to 0.2 mM methacholine, a muscarinic-cholinergic agonist, for 5 minutes before elevation of perfusion pressure blocked the pressure-induced increases in cAMP content, cAMP-dependent protein kinase activity, and rates of protein synthesis.
Negative_regulation (blocked) of Positive_regulation (increases) of kinase in hearts associated with agonist
3) Confidence 0.14 Published 1989 Journal Circ. Res. Section Abstract Doc Link 2475273 Disease Relevance 0.09 Pain Relevance 0.13
Amitriptyline-induced GDNF release was inhibited by U0126 (10 microM), a mitogen-activated protein kinase (MAPK)-extracellular signal-related kinase (ERK) kinase (MEK) inhibitor, but was not inhibited by H-89 (1 microM), a protein kinase A inhibitor, calphostin C (100 nM), a protein kinase C inhibitor and PD 169316 (10 microM), a p38 mitogen-activated protein kinase inhibitor.
Negative_regulation (inhibitor) of Positive_regulation (-extracellular) of kinase associated with endep and kinase c inhibitor
4) Confidence 0.11 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11595754 Disease Relevance 0.15 Pain Relevance 0.67
Amitriptyline-induced GDNF release was inhibited by U0126 (10 microM), a mitogen-activated protein kinase (MAPK)-extracellular signal-related kinase (ERK) kinase (MEK) inhibitor, but was not inhibited by H-89 (1 microM), a protein kinase A inhibitor, calphostin C (100 nM), a protein kinase C inhibitor and PD 169316 (10 microM), a p38 mitogen-activated protein kinase inhibitor.
Negative_regulation (inhibitor) of Positive_regulation (-extracellular) of kinase associated with endep and kinase c inhibitor
5) Confidence 0.11 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11595754 Disease Relevance 0.15 Pain Relevance 0.68
U0126 also blocked the amphetamine-induced increases in phospho-extracellular-regulated kinase and preproenkephalin and preprodynorphin gene expression in the striatum.
Negative_regulation (blocked) of Positive_regulation (increases) of kinase in striatum
6) Confidence 0.07 Published 2006 Journal Neuroscience Section Abstract Doc Link 16459022 Disease Relevance 0 Pain Relevance 0.11
The Janus tyrosine kinase inhibitor AG490, the selective protein kinase C (PKC) inhibitor, bisindolylmaleimide 1 (BIM1), as well as rottlerin, a selective blocker of the PKCdelta isoform, but not the cyclooxygenase inhibitor indomethacin, effectively reduced the effect.
Negative_regulation (inhibitor) of Positive_regulation (selective) of kinase associated with kinase c
7) Confidence 0.06 Published 2005 Journal Brain Section Abstract Doc Link 15817518 Disease Relevance 0.24 Pain Relevance 0.33
Inactivation of cAMP dependent-protein kinase (PKA) with a dominant inhibitory mutant strongly reduced PACAP-stimulated PENK transcription.
Negative_regulation (reduced) of Positive_regulation (Inactivation) of kinase
8) Confidence 0.03 Published 1998 Journal DNA Cell Biol. Section Abstract Doc Link 9502431 Disease Relevance 0.09 Pain Relevance 0
In addition, phosphorylation of JNK and ERK was also determined at 2, 4, 14 or 24 hours after LPS treatment to determine the kinetics of the kinase activation in lung tissue.


Spec (determined) Negative_regulation (determined) of Positive_regulation (activation) of kinase in lung
9) Confidence 0.02 Published 2004 Journal Respir Res Section Body Doc Link PMC538282 Disease Relevance 0 Pain Relevance 0.25
We report that nabumetone decreased uninvolved intestinal mucosal beta-catenin levels in the MIN mouse with a concomitant increase in glycogen synthase kinase (GSK)-3beta levels, an enzyme that targets beta-catenin for destruction.
Negative_regulation (decreased) of Positive_regulation (increase) of kinase
10) Confidence 0.01 Published 2005 Journal Cancer Lett. Section Abstract Doc Link 15617833 Disease Relevance 0.27 Pain Relevance 0.12

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