INT248146

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Context Info
Confidence 0.07
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.72
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (PLA2G6, PLA2G4A) aging (PLA2G4A) Golgi apparatus (PLA2G4A)
endoplasmic reticulum (PLA2G4A) cytosol (PLA2G4A) cell death (PLA2G6)
PLA2G6 (Homo sapiens)
PLA2G4A (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 1 100.00 Very High Very High Very High
Inflammation 72 87.20 High High
rheumatoid arthritis 5 70.16 Quite High
cytokine 10 68.80 Quite High
cINOD 18 5.00 Very Low Very Low Very Low
aspirin 5 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
Osteoarthritis 4 5.00 Very Low Very Low Very Low
Paracetamol 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 82 87.20 High High
Sepsis 2 70.88 Quite High
Rheumatoid Arthritis 5 70.16 Quite High
Rhinitis 1 69.28 Quite High
Disease 14 46.08 Quite Low
Cancer 9 5.00 Very Low Very Low Very Low
Osteoarthritis 4 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 3 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low
Dermatitis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was also demonstrated that quercetin selectively inhibited sPLA2-II, compared to its lower inhibition of sPLA2-IB.40 Quercetagetin, kaempferol-3-O-galactoside, and scutellarein inhibited human recombinant synovial PLA2 with IC50 values ranging from 12.2 to 17.6 ┬ÁM.41 Morelloflavone inhibited sPLA2 with its selectivity for Group II and III enzymes in vitro, including a high potency for the human recombinant synovial PLA2.42 Curcumin affects AA metabolism by blocking the phosphorylation of cPLA2, resulting in decreased COX-2 expression.24 Since PLA2 is coupled with COXs and LOXs (depending on the cells), the inhibitors of PLA2 may also cause the inhibition of COX or LOX activity.
PLA2 Negative_regulation (blocking) of Phosphorylation (phosphorylation) of cPLA2 associated with potency
1) Confidence 0.07 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2562783 Disease Relevance 0.72 Pain Relevance 0.40

General Comments

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