INT24815

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Context Info
Confidence 0.36
First Reported 1989
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 6.73
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (LDHA) small molecule metabolic process (LDHA) oxidoreductase activity (LDHA)
cytoplasm (LDHA)
Anatomy Link Frequency
pleural fluid 1
liver 1
platelet 1
pleura 1
lung 1
LDHA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 116 98.20 Very High Very High Very High
aspirin 100 95.92 Very High Very High Very High
Pain 21 88.40 High High
palliative 3 81.84 Quite High
Acute pain 2 77.20 Quite High
Thoracotomy 3 72.00 Quite High
cytokine 7 33.40 Quite Low
chemokine 2 32.52 Quite Low
ischemia 13 28.56 Quite Low
corticosteroid 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperuricemia 1 100.00 Very High Very High Very High
Hypocalcemia 1 100.00 Very High Very High Very High
Adult Respiratory Distress Syndrome 21 99.92 Very High Very High Very High
Myocardial Infarction 10 99.68 Very High Very High Very High
Malignant Neoplastic Disease 2 99.68 Very High Very High Very High
Solid Tumor 1 99.32 Very High Very High Very High
Infection 57 98.76 Very High Very High Very High
Tumor Lysis Syndrome 3 98.62 Very High Very High Very High
INFLAMMATION 127 98.20 Very High Very High Very High
Disease 40 97.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thoracentesis was performed on these patients for a sample of pleural fluid to determine pH, lactate dehydrogenase, glucose, protein levels, and blood cell count.
lactate dehydrogenase Spec (determine) Binding (determine) of in pleural fluid
1) Confidence 0.36 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2976737 Disease Relevance 0.99 Pain Relevance 0.04
By univariate analysis, age greater than 60, diffuse pattern, stage IV disease, involvement of liver, lung, pleura, or g-i tract, 'B' symptoms, surface heavy chain IgM or IgM-D, and LDH greater than 200 IU/dl were found to be significantly associated with a poor prognosis.
LDH Binding (associated) of in pleura associated with disease
2) Confidence 0.36 Published 1989 Journal Hematol Oncol Section Abstract Doc Link 2475420 Disease Relevance 0.76 Pain Relevance 0.08
Odds ratios for selected clinical complications comparing LDH groups for the NIH, CSSCD, and combined populations are presented in Figure 4 and Table S4.
LDH Binding (groups) of
3) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2330070 Disease Relevance 1.09 Pain Relevance 0.14
However, fatal outcomes were associated with decreased platelet counts, increased LDH, ARDS, cardiac failure, and lack of antiviral treatment in the bivariate analyses.
LDH Spec (analyses) Binding (associated) of in platelet associated with adult respiratory distress syndrome and myocardial infarction
4) Confidence 0.16 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2515635 Disease Relevance 0.37 Pain Relevance 0
By univariate analysis, age greater than 60, diffuse pattern, stage IV disease, involvement of liver, lung, pleura, or g-i tract, 'B' symptoms, surface heavy chain IgM or IgM-D, and LDH greater than 200 IU/dl were found to be significantly associated with a poor prognosis.
LDH Binding (associated) of in liver associated with disease
5) Confidence 0.12 Published 1989 Journal Hematol Oncol Section Abstract Doc Link 2475420 Disease Relevance 0.76 Pain Relevance 0.08
By univariate analysis, age greater than 60, diffuse pattern, stage IV disease, involvement of liver, lung, pleura, or g-i tract, 'B' symptoms, surface heavy chain IgM or IgM-D, and LDH greater than 200 IU/dl were found to be significantly associated with a poor prognosis.
LDH Binding (associated) of in lung associated with disease
6) Confidence 0.12 Published 1989 Journal Hematol Oncol Section Abstract Doc Link 2475420 Disease Relevance 0.76 Pain Relevance 0.08
= 0.822, p < 0.001), followed by LDH (Chi-square = 71.5, ?
LDH Binding (followed) of
7) Confidence 0.12 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1769412 Disease Relevance 0.70 Pain Relevance 0.21
As shown in Table 1, lactate triggering resulted in significantly more low exercise levels compared to the other two regimes (P < 0.001).Fig. 3RQmax (95% confidence interval) at low, target, and high exercise levels
lactate Binding (triggering) of
8) Confidence 0.09 Published 2007 Journal Dig Dis Sci Section Body Doc Link PMC1914298 Disease Relevance 0 Pain Relevance 0
LDH assay
LDH Binding (assay) of
9) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842433 Disease Relevance 0.12 Pain Relevance 0.16
Tumor lysis syndrome, which develops after effective therapy of malignant conditions and leads to hyperuricemia, hyperkaliemia, hyperphosphatemia, hypocalcemia and elevated lactate dehydrogenase, is uncommon in solid tumors.
lactate dehydrogenase Binding (leads) of associated with hyperuricemia, hypocalcemia, malignant neoplastic disease, solid tumor and tumor lysis syndrome
10) Confidence 0.02 Published 2001 Journal Ann. Ital. Med. Int. Section Abstract Doc Link 11688358 Disease Relevance 1.17 Pain Relevance 0.09

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