INT24817

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Context Info
Confidence 0.42
First Reported 1988
Last Reported 1989
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 0.39
Pain Relevance 1.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (POMC, VTN) extracellular region (POMC, VTN) small molecule metabolic process (POMC)
extracellular matrix organization (VTN) cell-cell signaling (POMC) cytoplasm (POMC)
Anatomy Link Frequency
plasma 2
POMC (Homo sapiens)
VTN (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 16 99.46 Very High Very High Very High
Inflammation 7 98.24 Very High Very High Very High
addiction 7 97.22 Very High Very High Very High
narcan 1 77.96 Quite High
Morphine 1 77.48 Quite High
Disease Link Frequency Relevance Heat
Injury 7 98.44 Very High Very High Very High
INFLAMMATION 7 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The interaction of beta H-endorphin with S protein bore characteristics of a ligand-receptor interaction, such as time dependence, reversibility, high affinity, saturability, and structural specificity and was mediated through the non-opioid COOH terminus of the beta H-endorphin molecule. beta H-Endorphin binding to S protein was observed at physiological pH or cation concentrations, indicating that the interaction may well occur in vivo.
H-Endorphin Binding (binding) of S protein associated with addiction and opioid
1) Confidence 0.42 Published 1989 Journal J. Biol. Chem. Section Abstract Doc Link 2475499 Disease Relevance 0 Pain Relevance 0.25
Human beta-endorphin (1-31) (beta H-endorphin) was found to specifically interact with purified complement S protein from human plasma.
beta-endorphin Binding (interact) of S protein in plasma
2) Confidence 0.42 Published 1989 Journal J. Biol. Chem. Section Abstract Doc Link 2475499 Disease Relevance 0 Pain Relevance 0.16
It is possible that the interaction of beta-endorphin with S protein is of physiological significance.
beta-endorphin Binding (interaction) of S protein
3) Confidence 0.41 Published 1988 Journal J. Biol. Chem. Section Abstract Doc Link 2828369 Disease Relevance 0 Pain Relevance 0.28
Human beta-endorphin (1-31) (beta H-endorphin) was found to specifically interact with purified complement S protein from human plasma.
H-endorphin Binding (interact) of S protein in plasma
4) Confidence 0.36 Published 1989 Journal J. Biol. Chem. Section Abstract Doc Link 2475499 Disease Relevance 0 Pain Relevance 0.16
The interaction of beta H-endorphin with S protein bore characteristics of a ligand-receptor interaction, such as time dependence, reversibility, high affinity, saturability, and structural specificity and was mediated through the non-opioid COOH terminus of the beta H-endorphin molecule. beta H-Endorphin binding to S protein was observed at physiological pH or cation concentrations, indicating that the interaction may well occur in vivo.
H-endorphin Binding (binding) of S protein associated with addiction and opioid
5) Confidence 0.32 Published 1989 Journal J. Biol. Chem. Section Abstract Doc Link 2475499 Disease Relevance 0 Pain Relevance 0.25
In view of S protein involvement in processes of inflammation and wound repair and beta-endorphin effects on immunocompetent cells, the demonstrated S protein-beta H-endorphin interaction appears to be of considerable functional significance.
H-endorphin Binding (interaction) of S protein associated with inflammation and injury
6) Confidence 0.31 Published 1989 Journal J. Biol. Chem. Section Abstract Doc Link 2475499 Disease Relevance 0.20 Pain Relevance 0.22
As found by chemical cross-linking beta H-endorphin bound to both, the 65- and 75-kDa molecular mass forms of S protein.
H-endorphin Binding (bound) of S protein
7) Confidence 0.31 Published 1989 Journal J. Biol. Chem. Section Abstract Doc Link 2475499 Disease Relevance 0 Pain Relevance 0.17
In view of S protein involvement in processes of inflammation and wound repair and beta-endorphin effects on immunocompetent cells, the demonstrated S protein-beta H-endorphin interaction appears to be of considerable functional significance.
H-endorphin Binding (interaction) of S protein associated with inflammation and injury
8) Confidence 0.31 Published 1989 Journal J. Biol. Chem. Section Abstract Doc Link 2475499 Disease Relevance 0.20 Pain Relevance 0.22

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