INT248184

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.25
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl1) extracellular region (Cxcl1) nucleus (DRGX)
Anatomy Link Frequency
neurons 3
Cxcl1 (Rattus norvegicus)
DRGX (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 21 99.98 Very High Very High Very High
Inflammation 42 99.80 Very High Very High Very High
Pain 42 97.68 Very High Very High Very High
addiction 18 71.84 Quite High
nav1.8 3 70.40 Quite High
Nav1.9 9 61.28 Quite High
adenocard 3 57.08 Quite High
chemokine 27 50.00 Quite Low
Neuronal excitability 3 50.00 Quite Low
Action potential 51 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 51 99.80 Very High Very High Very High
Pain 45 97.68 Very High Very High Very High
Nociception 27 96.48 Very High Very High Very High
Nervous System Injury 9 5.00 Very Low Very Low Very Low
Neuropathic Pain 3 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low
Body Weight 3 5.00 Very Low Very Low Very Low
Ganglion Cysts 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, the pro-inflammatory cytokine GRO/KC (CXCL1), which markedly increases in DRG during the early phase of several models of pathological pain, may exert important pro-nociceptive effects in part through its direct actions on nociceptive neurons.


GRO/KC Positive_regulation (increases) of DRG in neurons associated with nociception, pain, inflammation and cytokine
1) Confidence 0.02 Published 2008 Journal Mol Pain Section Body Doc Link PMC2562993 Disease Relevance 0.48 Pain Relevance 0.33
In summary, the pro-inflammatory cytokine GRO/KC (CXCL1), which markedly increases in DRG during the early phase of several models of pathological pain, may exert important pro-nociceptive effects in part through its direct actions on nociceptive neurons.


CXCL1 Positive_regulation (increases) of DRG in neurons associated with nociception, pain, inflammation and cytokine
2) Confidence 0.02 Published 2008 Journal Mol Pain Section Body Doc Link PMC2562993 Disease Relevance 0.48 Pain Relevance 0.33
In one study, GRO/KC-stimulated (acute) Ca2+ elevation in isolated DRG neurons could be observed at GRO/KC concentrations of 6.4 nM but was not significant at 1.2 nM [19].
GRO/KC Positive_regulation (elevation) of DRG in neurons
3) Confidence 0.02 Published 2008 Journal Mol Pain Section Body Doc Link PMC2562993 Disease Relevance 0.28 Pain Relevance 0.31

General Comments

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