INT24819

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.52
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (VTN) extracellular region (VTN) cell adhesion (VTN)
proteinaceous extracellular matrix (VTN) extracellular matrix organization (VTN)
Anatomy Link Frequency
plasma 1
macrophages 1
osteoblast 1
extracellular matrix 1
apoptotic cell 1
VTN (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 17 99.68 Very High Very High Very High
rheumatoid arthritis 75 98.24 Very High Very High Very High
Inflammatory response 7 96.20 Very High Very High Very High
cytokine 9 88.80 High High
Opioid 4 85.24 High High
addiction 5 80.76 Quite High
antagonist 9 75.68 Quite High
cINOD 2 74.64 Quite High
fibrosis 72 71.60 Quite High
dexamethasone 2 67.92 Quite High
Disease Link Frequency Relevance Heat
Adhesions 128 100.00 Very High Very High Very High
Osteoporosis 36 100.00 Very High Very High Very High
Apoptosis 24 98.92 Very High Very High Very High
Rheumatoid Arthritis 81 98.24 Very High Very High Very High
INFLAMMATION 23 96.20 Very High Very High Very High
Necrosis 3 90.52 High High
Autoimmune Disease 2 81.88 Quite High
Pulmonary Fibrosis 65 71.60 Quite High
Pneumonia 1 64.36 Quite High
Fibrosis 9 61.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results provide conclusive evidence that interactions of S protein with very different effectors led to similar conformational changes which uniformly resulted in exposure of a highly specific beta H-endorphin binding domain on S protein.
Positive_regulation (exposure) of S protein
1) Confidence 0.49 Published 1989 Journal J. Biol. Chem. Section Abstract Doc Link 2475499 Disease Relevance 0 Pain Relevance 0.24
The interaction of S protein with heparin as well as the adsorption of S protein to surfaces led to an almost 10-fold increase of specific binding which was due to the exposure of further beta H-endorphin-binding sites.
Positive_regulation (adsorption) of S protein
2) Confidence 0.43 Published 1989 Journal J. Biol. Chem. Section Abstract Doc Link 2475499 Disease Relevance 0 Pain Relevance 0.18
The 10-7 M adrenomedullin significantly enhanced RA-FLS adhesion to all three ECM proteins (Figure 1a), with a 2.39-, 2.25-, and 1.65-fold increase for vitronectin, fibronectin, and Coll.I, respectively (all with P < 0.0001).
Positive_regulation (increase) of vitronectin associated with rheumatoid arthritis and adhesions
3) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 0.86 Pain Relevance 0.13
Induction of a protein S/Mer tyrosine kinase-dependent apoptotic cell clearance pathway may contribute to the potent anti-inflammatory effects of glucocorticoids, representing a potential target for promoting resolution of inflammatory responses.
Positive_regulation (Induction) of protein S in apoptotic cell associated with inflammatory response, inflammation and apoptosis
4) Confidence 0.15 Published 2009 Journal J. Immunol. Section Abstract Doc Link 19597001 Disease Relevance 0.90 Pain Relevance 0.18
This integrin is a receptor for a wide variety of extracellular matrix ligands with an exposed RGD sequence, including vitronectin, fibronectin, fibrinogen, thrombospondin, proteolyzed collagen, von Willebrand factor, as well as osteopontin, and appears to play a critical role in cell migration [48].
Positive_regulation (proteolyzed) of vitronectin in extracellular matrix
5) Confidence 0.14 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.31 Pain Relevance 0.19
Glucocorticoids induce protein S-dependent phagocytosis of apoptotic neutrophils by human macrophages.
Positive_regulation (induce) of protein S in macrophages associated with inflammation and apoptosis
6) Confidence 0.11 Published 2009 Journal J. Immunol. Section Title Doc Link 19597001 Disease Relevance 0.84 Pain Relevance 0.29
Webster et al. have suggested that enhanced vitronectin adsorption, conformation and bioactivity are the major reason for increased osteoblast adhesion on nanophase alumina [437].
Positive_regulation (enhanced) of vitronectin in osteoblast associated with osteoporosis and adhesions
7) Confidence 0.08 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2871132 Disease Relevance 0.25 Pain Relevance 0
From a biologic point of view, resorption requires adhesion molecules (arginine-glycine-aspartic acid [RGD] sequence) for the attachment of osteoclastic cells to plasma and ECM, including FN, fibrinogen, vitronectin, type I collagen, osteopontin, and bone sialoprotein [44].
Positive_regulation (requires) of vitronectin in plasma associated with osteoporosis and adhesions
8) Confidence 0.01 Published 2010 Journal Journal of Periodontal & Implant Science Section Body Doc Link PMC2967808 Disease Relevance 0.36 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox