INT2482

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Context Info
Confidence 0.59
First Reported 1979
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 2.62
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (REN) extracellular space (REN) extracellular region (REN)
intracellular (REN) response to stress (REN)
Anatomy Link Frequency
plasma 4
sinus 2
epithelial cell 2
heart 2
REN (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 1 97.68 Very High Very High Very High
alcohol 11 97.62 Very High Very High Very High
agonist 1 96.84 Very High Very High Very High
beta blocker 7 83.68 Quite High
anesthesia 7 80.64 Quite High
antagonist 3 79.92 Quite High
halothane 1 68.88 Quite High
COX-2 inhibitor 3 55.36 Quite High
cytokine 1 51.60 Quite High
COX2 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 62 100.00 Very High Very High Very High
Heart Rate Under Development 14 99.96 Very High Very High Very High
Pressure Volume 2 Under Development 5 99.44 Very High Very High Very High
Alcohol Addiction 11 97.74 Very High Very High Very High
Hypotension 6 96.88 Very High Very High Very High
Adult Respiratory Distress Syndrome 61 94.08 High High
Aids-related Complex 1 88.48 High High
Left Ventricular Dysfunction 3 83.20 Quite High
Hypertension 8 75.00 Quite High
Cerebral Aneurysm 1 58.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Perfusion of a beta-adrenergic blocker (propranolol) or an alpha-adrenergic blocker (phentolamine) through the third and fourth cerebroventricles had no effect on the increase in renin during sinus hypotension, whereas centrally administered clonidine, and alpha-agonist, blocked the response.
Neg (no) Regulation (effect) of Positive_regulation (increase) of renin in sinus associated with pressure volume 2 under development, agonist and clonidine
1) Confidence 0.59 Published 1982 Journal Am. J. Physiol. Section Abstract Doc Link 7039357 Disease Relevance 0.27 Pain Relevance 0.15
As the half-life of plasma renin is 15 min, the data suggest that the persistently increased plasma renin activity is probably responsible for the increase of arterial pressure following sodium nitroprusside-induced hypotension.
Regulation (responsible) of Positive_regulation (increased) of plasma renin in plasma associated with hypotension
2) Confidence 0.38 Published 1979 Journal Anesthesiology Section Abstract Doc Link 453612 Disease Relevance 0.55 Pain Relevance 0.24
Activation of the renin┬ľangiotensin system is a typical feature in chronic heart failure and its inhibition remains an important therapeutic target in these patients.
Regulation (target) of Positive_regulation (Activation) of renin in heart associated with myocardial infarction
3) Confidence 0.38 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788599 Disease Relevance 0.82 Pain Relevance 0.08
These experiments were conducted to examine the effects of prostaglandin synthesis inhibitors on basal and isoproterenol-induced plasma renin concentration and renin gene expression in the late-gestation fetal lamb.
Spec (examine) Regulation (effects) of Spec (examine) Positive_regulation (isoproterenol-induced) of plasma renin in plasma
4) Confidence 0.30 Published 2003 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 12456386 Disease Relevance 0 Pain Relevance 0.11
They claimed that alcohol abuse impairs immune function, decreases pulmonary antioxidant capacity, decreases alveolar epithelial cell function, alters activation of the renin angiotensin system, and impairs GM-CSF signaling [19].
Regulation (alters) of Positive_regulation (activation) of renin in epithelial cell associated with alcohol
5) Confidence 0.02 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2936288 Disease Relevance 0.99 Pain Relevance 0.34

General Comments

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